Anti-Inflammation Activity of Ethyl Acetate Extract of Malacca Leaves (Phyllanthus emblica)

DOI

10.2991/absr.k.210420.018How to use a DOI?

Keywords

Malacca leaf, carrageenan, ethyl acetate extract, volume edema

Abstract

This study aims to evaluate the anti-inflammation activity of ethyl acetate extract of Malacca leaf (Phyllanthus emblica) in mice. The study used 25 mice which were induced by subcutaneous injection of 1 % carrageenan. The mice were divided into 5 treatment groups: K1 was negative control, K2 (positive control) was given piroxicam suspension at dose of 20 mg/kg BW, while K3, K4, and K5 were given Malacca leaf extract at dose of 100, 200, and 300 mg/kg BW, respectively, by oesophageal intubation for 4 days. On day 5, the edema volume was measured and the differential leucocytes were counted. The data were analyzed using one way Analysis of variance (ANOVA). The lowest edema volume was observed in mice treated with different doses of Malacca leaves extract (K2, K3, K4) and significantly different (P<0.05) compared to mice in K1 and K2. The percentage of neutrophils was significantly lower in groups K2, K3, K4, and K5 than in groups K1. In contrast, the percentage of eosinophil, lymphocytes and monocytes were significantly higher (P<0.05) in K2, K3, K3, and K4 as compared to those in K1. The basophils percentage were similar among the groups, except for K4 which had the highest value (P<0.05) compared to other groups. It is concluded that the administration of ethyl acetate extract of Malacca leaves can reduce the edema volume and affect the number of leukocytes in carrageenan-induced mice.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Nuzul Asmilia
AU  - Teuku Armansyah
AU  - Herrialfian Herrialfian
AU  - Rinidar
AU  - Abdul Harris
AU  - Arman Sayuti
AU  - Nazaruddin
AU  - Cindy Ary Ristanti
AU  - Indriana Oktavani
PY  - 2021
DA  - 2021/04/21
TI  - Anti-Inflammation Activity of Ethyl Acetate Extract of Malacca Leaves (Phyllanthus emblica)
BT  - Proceedings of the 2nd International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2020)
PB  - Atlantis Press
SP  - 81
EP  - 86
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.210420.018
DO  - 10.2991/absr.k.210420.018
ID  - Asmilia2021
ER  -