Potential Roles of Extracellular Traps in the Progression of Coronavirus Disease (Covid)-19

DOI

10.2991/assehr.k.210305.001How to use a DOI?

Keywords

Extracellular Traps, Etosis, Thrombosis, Inflammation, Coronavirus

Abstract

Millions of people have suffered from coronavirus disease (COVID)-19 worldwide with diverse clinical presentations, ranging from asymptomatic to severe pneumonia leading to respiratory failure and even death. In critical phases, thrombosis and inflammation are considered as the important contributors in the processes. Extracellular traps (ETs), meshes-like chromatin DNA decorated with antimicrobial proteins, have become interesting features in immunothrombosis research due to their pro-inflammatory, pro-thrombotic and pro-coagulant properties. These traps, released by innate inflammatory cells, mark a distinct form of cell death namely etosis. Whether etosis may also participate in the thrombotic inflammation of Covid-19 progression and whether the roles are beneficial or detrimental are still not much known. This review presents current knowledge on the formation, properties and roles of ETs in human non-infectious diseases, particularly in inflammation, thrombosis and coagulopathy, followed by an exploration on how SARS-CoV2 may trigger the formation of ETs. Next, the pathogenesis of Covid-19 is briefly discussed, gathering current findings on the involvement of ETs in the immunopathological mechanisms during Covid-19 infection. Lastly, this review discusses the potential roles of etosis in the progression of Covid-19, thereby targeting the extracellular traps as a severity biomarker and/or a therapeutic approach in the management of Covid-19.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Kartika R Pertiwi
PY  - 2021
DA  - 2021/03/08
TI  - Potential Roles of Extracellular Traps in the Progression of Coronavirus Disease (Covid)-19
BT  - Proceedings of the 7th International Conference on Research, Implementation, and Education of Mathematics and Sciences (ICRIEMS 2020)
PB  - Atlantis Press
SP  - 1
EP  - 7
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.210305.001
DO  - 10.2991/assehr.k.210305.001
ID  - Pertiwi2021
ER  -