Relations between ER Stress, UPR and Cancer Biology

DOI

10.2991/assehr.k.220110.056How to use a DOI?

Keywords

Cancer; ER Stress; Immunotherapy; UPR; Microenvironment

Abstract

Effects of external factors such as protein homeostasis can trigger the production of endoplasmic reticulum stress, which can be restored by the unfolded protein response (UPR). The UPR plays a central role in the development of cancer biology, and it is also associated with various malignant characteristics, such as invasion and metastasis. Malignant cells can thrive under various conditions, such as hypoxia, which limits their ability to produce protein-folding, and this impairs their ability to generate an anti-tumor immune response. Studies have also revealed that the effects of ER stress on the development of cancer immunity are significant, this concept proposes that the use of targeted drugs to address this issue could help improve the efficacy of currently available cancer immunotherapies. In this paper, we discussed the impact of ER stress and UPR on cancer treatment, and their implications with cancer biology. We concluded that UPR induced by ER stress in cancer cells has the ability to mutate and use this feature to play its own advantages. This is another reason why UPR can be regarded as an anti-cancer treatment mechanism.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Yixuan Wang
AU  - Jinrui Huang
AU  - Siqi Xiong
PY  - 2022
DA  - 2022/01/28
TI  - Relations between ER Stress, UPR and Cancer Biology
BT  - Proceedings of the 2021 International Conference on Public Art and Human Development ( ICPAHD 2021)
PB  - Atlantis Press
SP  - 289
EP  - 292
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220110.056
DO  - 10.2991/assehr.k.220110.056
ID  - Wang2022
ER  -