Expression of MicroRNA-155 in Hepatitis B Virus-Related to Hepatocellular Carcinoma
- DOI
- 10.2991/ahsr.k.210115.003How to use a DOI?
- Keywords
- MicroRNA-155, HBV Infection, Hepatocellular carcinoma
- Abstract
Hepatitis B virus (HBV) infection is still a global health problem and a major precipitation factor for hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) consist of small non-coding RNAs that regulate gene expression at the post-transcriptional level, thus involving in primary biological processes, including proliferation, differentiation, and apoptosis of cells. MicroRNA-155 is known as an oncogene in some cancer cells and has a relationship with the severity of cancer cells. Here, we investigated the level of microRNA-155 expression in hepatocellular carcinoma patients associated with HBV infection. It was found that the expression of microRNA-155 in the blood plasma of HBV-related to HCC patients was higher and up-regulated by 2.33-fold compared to the blood plasma of HCC patients without HBV infection. This result suggests that microRNA-155 may have a major regulatory role in hepatocarcinogenesis associated with hepatitis B infection and potentially be a therapeutic target for HBV patients developing HCC treatment.
- Copyright
- © 2021, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Dede Renovaldi AU - Juwita Radityaningsih AU - Puji Lestari AU - Nanda Qoriansas AU - Didik Setyo Heriyanto AU - Neneng Ratnasari AU - Sofia Mubarika Haryana PY - 2021 DA - 2021/01/16 TI - Expression of MicroRNA-155 in Hepatitis B Virus-Related to Hepatocellular Carcinoma BT - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020) PB - Atlantis Press SP - 12 EP - 16 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.210115.003 DO - 10.2991/ahsr.k.210115.003 ID - Renovaldi2021 ER -