The Outcomes of Invitro Fertilization and Embryo Transfer in Endometriosis-Associated Infertility: A Case Control Study

DOI

10.2991/icosihsn-19.2019.10How to use a DOI?

Keywords

endometriosis, embryo transfer, infertility, in vitro fertilization, pregnancy rate

Abstract

The pathophysiology of infertility in endometriosis is still controversial and widely investigated. Several mechanisms are put forward. Whether In Vitro Fertilization-Embryo Transfer (IVF-ET) program in endometriosis is a solution to improve the fertility still needs further studied. Objective : To compare the output of IVF-ET between endometriosis infertility and that of non-endometriosis infertility. Methods : This research is non experimental research with case control design. A retrospective approach with secondary data was conducted in 2017. The samples are fifty endometrial infertility patients and fifty infertility tubal factor and or sperm undergoing IVF-ET program at Permata Hati Clinic, Dr. Sardjito Hospital Yogyakarta. Results : The research output is fertilization rate, i.e. a number of good quality embryo and the success of pregnancy based on pregnancy test. Data analysis was done by statistical test of T test and Chi Square. Multivariate analysis was done by logistic regression. Characteristics of both study groups are similar: in terms of age, BMI, duration of infertility, basal FSH, basal E2, stimulation type and gonadotropin needs. A number of good quality embryos in endometriosis group is lower (2.34 ± 2.33 vs 3.44 ± 2.97; p <0.039), but the fertilization rate is the same (48.58 ± 27.16 vs 55.19 ± 30.9; p > 0.259). Compared to non-endometriosis, endometriosis group has bigger risk of pregnancy failure (OR 3.758; CI95% 1.11-12.68; p <0.03). Conclusion : There is no difference in fertilization rates between endometriosis and non-endometriosis. The number of good quality embryo on endometriosis group is lower than non-endometriosis. Pregnancy failure on endometriosis group is higher than non-endometriosis group.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Alfaina Wahyuni
PY  - 2019/10
DA  - 2019/10
TI  - The Outcomes of Invitro Fertilization and Embryo Transfer in Endometriosis-Associated Infertility: A Case Control Study
BT  - Proceedings of the Third International Conference on Sustainable Innovation 2019 – Health Science and Nursing (IcoSIHSN 2019)
PB  - Atlantis Press
SP  - 40
EP  - 44
SN  - 2468-5739
UR  - https://doi.org/10.2991/icosihsn-19.2019.10
DO  - 10.2991/icosihsn-19.2019.10
ID  - Wahyuni2019/10
ER  -