The Effects of Oleuropein Isolate on Apoptosis Inducing Factor and High Mobility Group Box-1 Levels In Traumatic Brain Injury Model Rats

DOI

10.2991/978-94-6463-310-8_2How to use a DOI?

Keywords

Oleuropein Isolate; Apoptosis-Inducing Factor; High Mobility Group Box-1

Abstract

Background

Traumatic brain injury is a major public problem with an incidence of 10 million people annually, causing the most significant deaths and disabilities worldwide. Head injuries can be classified into primary and secondary head injuries. Secondary head injuries can be caused by ischemia, cerebral oedema, and neuroinflammation. AIF and HMGB-1 are two parameters that can be indicators in measuring the effect of Oleuropein on traumatic brain injury in rats. Oleuropein has many activities, such as antioxidant, anti-apoptotic, antimicrobial, anti-inflammatory, and neuroprotective.

Method

This laboratory study used a simple random sampling technique to select experimental animals and homogenous experimental locations. The study was conducted with a pre-test and post-test control group design to compare treatment effects in the experimental and control groups. Observations were made from the first 24 hours up to 72 hours after the onset of head injury, with the administration of Oleuropein intraperitoneally.

Result

The results showed that Oleuropein reduced AIF and HMGB-1 levels in rats with traumatic brain injury. This indicates that Oleuropein has a neuroprotective effect by reducing inflammation and apoptosis.

Conclusion

Oleuropein has a potential neuroprotective effect in traumatic brain injury by reducing inflammation and apoptosis. Therefore, Oleuropein can be considered as a potential therapeutic agent for traumatic brain injury in the future.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Abdurrahman Mousa Arsyad
PY  - 2023
DA  - 2023/12/18
TI  - The Effects of Oleuropein Isolate on Apoptosis Inducing Factor and High Mobility Group Box-1 Levels In Traumatic Brain Injury Model Rats
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 4
EP  - 23
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_2
DO  - 10.2991/978-94-6463-310-8_2
ID  - Arsyad2023
ER  -