Association of the MCP-1 -2518 A/G Polymorphism with Schizophrenia Risk: Insights from a Batak Ethnic Group Study

DOI

10.2991/978-94-6463-310-8_15How to use a DOI?

Keywords

schizophrenia; polymorphism; MCP-1; Batak tribe; control group

Abstract

Background

A genetic variation called the monocyte chemoattractant protein-1 (MCP-1) -2518 A/G polymorphism can affect a person's inflammatory response and MCP-1 gene expression. Several studies suggested this polymorphism to be potentially linked to the risk of developing schizophrenia, a complex and multifactorial condition involving the interaction between genetic and environmental factors. Recently, individuals carrying the G allele of the MCP-1 -2518 A/G have been implicated with increased susceptibility to schizophrenia compared to those homozygous for the A allele. However, other factors contributing to the development need to be considered. Further studies are required to understand better the relationship between the MCP-1 -2518 A/G and schizophrenia risk.

Method

400 individuals, including 200 schizophrenia patients and 200 healthy Batak controls, were sampled using a non-probability purposive sampling method. The RFLP and PCR techniques were used to study the MCP-1 -2518 A/G polymorphism.

Result

With a p-value of 0.2, an odds ratio (OR) of 0.82, and a 95% confidence interval (CI) spanning from 0.62 to 1.09, the frequency of the A and G alleles did not differ substantially between the schizophrenia and control groups. However, the genotypes (AG vs GG) showed a significant correlation with an OR of 3.167, a 95% CI (confidence interval) of 1.889 to 5.311, and p 0.01. With p= 0.157, an OR of 1.557, and a 95% confidence interval (CI) spanning from 0.085 to 0.633, there was no statistically significant connection between AA and GG.

Conclusion

The MCP-1 -2518 A/G polymorphism may be linked to a risk of schizophrenia, according to this study. To validate these findings and clarify the underlying mechanisms connecting MCP-1 and schizophrenia, additional research was needed.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Janiasman Alexandro Sinurat
AU  - Mustafa M. Amin
AU  - M. Surya Husada
PY  - 2023
DA  - 2023/12/18
TI  - Association of the MCP-1 -2518 A/G Polymorphism with Schizophrenia Risk: Insights from a Batak Ethnic Group Study
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 104
EP  - 109
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_15
DO  - 10.2991/978-94-6463-310-8_15
ID  - Sinurat2023
ER  -