Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)

Association of the MCP-1 -2518 A/G Polymorphism with Schizophrenia Risk: Insights from a Batak Ethnic Group Study

Authors
Janiasman Alexandro Sinurat1, Mustafa M. Amin1, *, M. Surya Husada1
1Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
*Corresponding author. Email: mustafamamin@gmail.com
Corresponding Author
Mustafa M. Amin
Available Online 18 December 2023.
DOI
10.2991/978-94-6463-310-8_15How to use a DOI?
Keywords
schizophrenia; polymorphism; MCP-1; Batak tribe; control group
Abstract
Background

A genetic variation called the monocyte chemoattractant protein-1 (MCP-1) -2518 A/G polymorphism can affect a person's inflammatory response and MCP-1 gene expression. Several studies suggested this polymorphism to be potentially linked to the risk of developing schizophrenia, a complex and multifactorial condition involving the interaction between genetic and environmental factors. Recently, individuals carrying the G allele of the MCP-1 -2518 A/G have been implicated with increased susceptibility to schizophrenia compared to those homozygous for the A allele. However, other factors contributing to the development need to be considered. Further studies are required to understand better the relationship between the MCP-1 -2518 A/G and schizophrenia risk.

Method

400 individuals, including 200 schizophrenia patients and 200 healthy Batak controls, were sampled using a non-probability purposive sampling method. The RFLP and PCR techniques were used to study the MCP-1 -2518 A/G polymorphism.

Result

With a p-value of 0.2, an odds ratio (OR) of 0.82, and a 95% confidence interval (CI) spanning from 0.62 to 1.09, the frequency of the A and G alleles did not differ substantially between the schizophrenia and control groups. However, the genotypes (AG vs GG) showed a significant correlation with an OR of 3.167, a 95% CI (confidence interval) of 1.889 to 5.311, and p 0.01. With p= 0.157, an OR of 1.557, and a 95% confidence interval (CI) spanning from 0.085 to 0.633, there was no statistically significant connection between AA and GG.

Conclusion

The MCP-1 -2518 A/G polymorphism may be linked to a risk of schizophrenia, according to this study. To validate these findings and clarify the underlying mechanisms connecting MCP-1 and schizophrenia, additional research was needed.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
Series
Advances in Health Sciences Research
Publication Date
18 December 2023
ISBN
978-94-6463-310-8
ISSN
2468-5739
DOI
10.2991/978-94-6463-310-8_15How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

TY  - CONF
AU  - Janiasman Alexandro Sinurat
AU  - Mustafa M. Amin
AU  - M. Surya Husada
PY  - 2023
DA  - 2023/12/18
TI  - Association of the MCP-1 -2518 A/G Polymorphism with Schizophrenia Risk: Insights from a Batak Ethnic Group Study
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 104
EP  - 109
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_15
DO  - 10.2991/978-94-6463-310-8_15
ID  - Sinurat2023
ER  -