Differences in 5-HT6 C267T Gene Receptor Polymorphism Between People with Schizophrenia and Health Controls from the Batak Tribe

DOI

10.2991/978-94-6463-310-8_13How to use a DOI?

Keywords

Batak Ethnic Group; Serotonin; 5-HT6 Gene; Polymorphism

Abstract

Schizophrenia is a chronic mental disorder that affects human psychosocial functioning. Approximately 24 million people worldwide are estimated to suffer from this disorder, with the onset typically occurring in late adolescence or early twenties. People with Schizophrenia (PWS) have a higher risk of premature death, in which environmental and psychological factors influence the development. Furthermore, the serotonin system plays a vital role in the pathogenesis of schizophrenia, and the serotonin 5-HT6 receptor gene is associated with its development. The “serotonin-dopamine” hypothesis states that an increase in dopaminergic and serotonergic neurotransmission in subcortical areas and a decrease in activity in the prefrontal cortex cause positive and negative symptoms.

Method This study used an analytical comparative method with an observational analysis design. The samples were selected using consecutive non-probability sampling, with 145 PWS patients and 145 healthy controls from the Batak ethnic group. The analytical tests used were Chi-Square and logistic regression.

Results The PWS group was dominated by male subjects, with 93 people (64.1%), while in the healthy control group, there were 126 males (86.9%). The median age was 35 years and 24 years in both groups respectively. The median onset of disease in the PWS group was 25 years, and the median length was eight years. The T allele was the most frequently found in the PWS group, with 218 occurrences (75.2%), while in control, it was found 216 times (74.5%) with a p-value of 0.84. In the logistic regression analysis, the p-values for genotypes CC vs TT and CT vs. TT were 0.673 and 0.963, respectively.

Conclusion This study did not find a relationship between the 5-HT6 C267T gene with schizophrenia in the Batak ethnic group and their control group.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - S. Fitri Ana Ima
AU  - Mustafa M. Amin
AU  - Elmeida Effendy
PY  - 2023
DA  - 2023/12/18
TI  - Differences in 5-HT6 C267T Gene Receptor Polymorphism Between People with Schizophrenia and Health Controls from the Batak Tribe
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 92
EP  - 97
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_13
DO  - 10.2991/978-94-6463-310-8_13
ID  - Ima2023
ER  -