Candidate IL-1β -511C/T Polymorphism in Schizophrenia Patients in Batak Tribe

DOI

10.2991/978-94-6463-120-3_17How to use a DOI?

Keywords

schizophrenia; variant; interleukin-1β; interleukin-2; Bataknese; control

Abstract

Background: There are approximately 20 million cases of schizophrenia worldwide. This complication can result from developmental processes, neurodegenerative, and neurotransmitter disorders to the occurrence of infectious or autoimmune processes. Furthermore, serotonin, noradrenaline, dopamine, and glutamate are just a few of the neurotransmitters that cytokines may play a role in controlling. The relationships between glutamate and dopamine seem to be important for understanding the pathophysiology of schizophrenia. According to cellular receptors and the intracellular environment, which serve as risk factors for schizophrenia, IL-1 is involved in neurodevelopmental processes and can have neurotoxic or neuroprotective effects.

Method: Non-probability purposive sampling was conducted on 240 subjects (120 people with schizophrenia (ODS) and 120 healthy control of Batak tribe) hospitalized at Prof. M. ILDREM Medan, Indonesia, as normal control and East Medan Sub-district as healthy control. In addition, the IL-1β -511 C/T Polymorphism was analyzed using RFLP and PCR methods.

Result: The -511Allele frequency of the IL-β -511 C/T (rs16944) polymorphism was different between cases and controls with a p-value of 0.001 and OR of 1.901 and a 95% confidence interval between 1.322 to 2.735. The p-value for the genotype (CC vs. TT) was 0.019 with an OR of 0.414 and a 95% CI between 0.198–0.866. Meanwhile, the p-value for the genotype (CT vs TT) was 0.388 with an OR of 0.746 and a 95% CI between 0.384–1.451.

Conclusion: The results showed that the IL-1β -511 C/T polymorphism has a relationship with the incidence of schizophrenia, and may be a risk factor for schizophrenia in Batak people.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Syaifuddin Nasution
AU  - Elmeida Effendy
AU  - Mustafa M. Amin
PY  - 2023
DA  - 2023/03/31
TI  - Candidate IL-1β -511C/T Polymorphism in Schizophrenia Patients in Batak Tribe
BT  - Proceedings of the 5th International Conference on Neuroscience, Neurology and Psychiatry (ICONAP 2022)
PB  - Atlantis Press
SP  - 107
EP  - 112
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-120-3_17
DO  - 10.2991/978-94-6463-120-3_17
ID  - Nasution2023
ER  -