CASE REPORT: Paget’s Disease with Secondary Encephalopathy

DOI

10.2991/978-94-6463-120-3_2How to use a DOI?

Keywords

Paget’s Disease; Secondary Encephalopathy; Anaemia

Abstract

Introduction: Paget’s disease is a metabolic disorder of bone in which osteoclasts are more active than osteoblasts, resulting in increased bone resorption and compensated by excessive formation of new bone contributed by osteoblasts. Bones affected with Paget’s Disease stimulate hypervascularization, leading to diversion of blood circulation to that area that can be accompanied by neurological diseases such as cerebral disorders or secondary encephalopathy and other complications such as anaemia.

Case Report: A 68-year-old woman (MG) was admitted to our hospital after suddenly becoming unconscious two hours earlier. Neurological examination revealed a sensorium sopor with a GCS (Glasgow Coma Scale) score of E1M2V2. Chest X-ray showed the impression of cardiomegaly, and plain radiographs of the lumbar vertebrae were radiolucent, indicating increased bone density on the first lumbar. A non-contrast head CT scan showed lytic lesions in the right parietal and temporal-occipital bones, indicating Paget’s disease. The patient suffered from respiratory acidosis and anaemia; hence metabolic correction was initially addressed. The patient was also planned for a serum alkaline phosphatase check-up for bisphosphonate therapy.

Discussion: Paget’s disease is a disorder of bone metabolism that can occur together with neurological diseases such as cerebral disorders or secondary encephalopathy with anaemia. The diagnosis of Paget’s disease is made based on the history, clinical symptoms, serum alkaline phosphatase, and radiological examination. Therefore, disease management is more likely to focus on supportive approaches and medical care.

Copyright

© 2023 The Author(s)

Open Access

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TY  - CONF
AU  - Alfansuri Kadri
AU  - Eko Yandra
PY  - 2023
DA  - 2023/03/31
TI  - CASE REPORT: Paget’s Disease with Secondary Encephalopathy
BT  - Proceedings of the 5th International Conference on Neuroscience, Neurology and Psychiatry (ICONAP 2022)
PB  - Atlantis Press
SP  - 4
EP  - 10
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-120-3_2
DO  - 10.2991/978-94-6463-120-3_2
ID  - Kadri2023
ER  -