A Bibliometric Analysis of mTOR Expression in Breast Cancer

DOI

10.2991/978-94-6463-604-8_14How to use a DOI?

Keywords

mTOR; breast cancer; bibliometric

Abstract

The mTOR (mechanistic Target of Rapamycin) pathway represents a critical focus in cancer research, playing a pivotal role in cellular growth, proliferation, and survival. This study presents a comprehensive bibliometric analysis of research publications focusing on mTOR in breast cancer from 2006 to 2023, utilizing the Scopus database. This study conducted a bibliometric analysis of publications related to mTOR in breast cancer from 2006 to 2023. Data were extracted from Scopus database using a systematic search strategy, and only English-language articles focusing on human studies were included. Analytical tools, including Harzing’s Publish or Perish, VOSviewer, and CiteSpace, were employed to examine citation metrics, collaboration networks, and thematic clusters within the field, providing insights into global research trends and key areas of focus. Our analysis revealed a significant growth in publication rate, particularly between 2018 and 2022. Asia, North America and Europe, dominate reseach publications with a substansial contribution from China and the United States, Network analysis identified five primary research clusters: oncogenic pathways, therapeutic targeting, multi drug resistance mechanisms, genomic insights, and clinical biomarkers. The findings indicate that although mTOR-targeted therapies show promise, particularly in overcoming treatment resistance in hormone receptor-positive subtypes, limited understanding of the pathway’s interactions remains a challenge. This bibliometric study offers a comprehensive view of mTOR research trends in breast cancer, identifying key research clusters and revealing geographical disparities in research contributions. The study suggests that expanding international collaborations and integrating multi-omics data could advance personalized therapies and promote equitable progress in breast cancer treatment globally. Future investigations should focus on bridging research gaps and fostering interdisciplinary efforts to deepen understanding of mTOR’s role in breast cancer biology.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Indri Windarti
AU  - Ety Apriliana
AU  - Susianti Susianti
PY  - 2024
DA  - 2024/12/19
TI  - A Bibliometric Analysis of mTOR Expression in Breast Cancer
BT  - Proceedings of the International Conference on Medical Science and Health (ICOMESH 2024)
PB  - Atlantis Press
SP  - 159
EP  - 170
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-604-8_14
DO  - 10.2991/978-94-6463-604-8_14
ID  - Windarti2024
ER  -