Proceedings of the International Conference on Medical Science and Health (ICOMESH 2024)

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Effect of Stachytarpheta sp. Leaf Extract In Alloxan-Induced Mice

Authors
Iffa Afiqa Khairani1, *, Fiki Lusiana1, Jeane Siswitasari Mulyana1, Elisa Nurma Riana1, Yanti Ariyanti1, Silvia Andriani2
1Department of Biology, Faculty of Sciences, Institut Teknologi Sumatera, South Lampung, Sumatera, Lampung, Indonesia
2Medical Laboratory Technology Department, Faculty of Health, Universitas Muhammadiyah Pringsewu, North Pringsewu, Pringsewu, Lampung, Indonesia
*Corresponding author. Email: iffa.khairani@bi.itera.ac.id
Corresponding Author
Iffa Afiqa Khairani
Available Online 19 December 2024.
DOI
10.2991/978-94-6463-604-8_23How to use a DOI?
Keywords
Alloxan; Blood Sugar; Erythrocytes; Leukocytes; Stachytarpheta sp
Abstract

Diabetes is characterized by elevated blood sugar levels or hyperglycemia. Diabetes can lead to decreased erythrocyte and hemoglobin levels, as well as increased leukocyte counts. This study aimed to analyze the phytochemical content of Stachytarpheta sp. Leaf extract and evaluate its protective effects on blood sugar levels and blood profiles of mice, including hemoglobin levels, total erythrocyte, and total leukocyte in alloxan-induced diabetic mice. The study included five treatment groups: K1 (normal), K2 (aquades 0.3 ml), and three treatment groups receiving varying doses of Stachytarpheta sp. Leaf extract (P1: 200 mg/kg BW; P2: 300 mg/kg BW; P3: 400 mg/kg BW) administered for 15 days. Afterward, groups K2, P1, P2, and P3 were induced with alloxan 170 mg/kg BW and measured blood sugar levels 5 days after induction. Results indicated that Stachytarpheta sp. Leaf extract contains phytochemical compounds such as flavonoids, alkaloids, tannins, saponins, and terpenoids. Blood sugar levels measured after alloxan induction showed hyperglycemia in K2, while P1, P2, and P3 showed normal blood sugar levels. The leaf extract demonstrated a protective effect against hyperglycemia and influenced erythrocyte and leukocyte counts, but had no significant effect on hemoglobin levels.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International Conference on Medical Science and Health (ICOMESH 2024)
Series
Advances in Health Sciences Research
Publication Date
19 December 2024
ISBN
978-94-6463-604-8
ISSN
2468-5739
DOI
10.2991/978-94-6463-604-8_23How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Iffa Afiqa Khairani
AU  - Fiki Lusiana
AU  - Jeane Siswitasari Mulyana
AU  - Elisa Nurma Riana
AU  - Yanti Ariyanti
AU  - Silvia Andriani
PY  - 2024
DA  - 2024/12/19
TI  - Effect of Stachytarpheta sp. Leaf Extract In Alloxan-Induced Mice
BT  - Proceedings of the International Conference on Medical Science and Health (ICOMESH 2024)
PB  - Atlantis Press
SP  - 263
EP  - 272
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-604-8_23
DO  - 10.2991/978-94-6463-604-8_23
ID  - Khairani2024
ER  -