Literature Review of Atherosclerosis Treatment with Hibiscus Sabdariffa as an Alternative for Statin Therapy

DOI

10.2991/978-94-6463-208-8_8How to use a DOI?

Keywords

Atherosclerosis; Hibiscus sabdariffa; Statin

Abstract

Coronary heart disease (CHD) ranks the second-highest cause of mortality after stroke, thereby emphasizing CHD as the most significant contributor to cardiovascular disease (CVD) mortality. Statin therapy serves as an efficacious treatment in regressing the number of CHD cases. However, current studies highlighted a prolonged side effect of statin therapy; thereby, a more effective, safe and alternative effort is required in addressing such notion. Hibiscus sabdariffa (HS) is currently an alternative herbal treatment to treat CHD due to atherosclerosis prevalence. Thus, this literature review examines HS potential as an alternative and less risky approach in statin therapy. In compiling this literature review, the PRISMA method was applied, cited through articles and journals sourced from 6 databases: PubMed, Google Scholar, NCBI, MDPI, ScienceDirect, and SpringerLink. Researches indicated that HS contained phytochemicals, depicted an active role in minimizing risk factors for atherosclerosis. Anthocyanins and polyphenols comprised the phytochemicals stored by HS. Anthocyanins worked as an inhibitor of Low-Density Lipoprotein (LDL) oxidation, acted as a potent antioxidant and a high blood pressure-lowering factor.

Meanwhile, polyphenol compounds played a role in overcoming hypercholesterolemia which generated a risk factor for atherosclerosis. These two compounds further proved that HS could offer an alternative treatment for CHD due to atherosclerosis prevalence. In sum, this literature review encouraged further researches highlighting the toxicity tests and the appropriate dose to observe HS potency while utilizing a broader sample of Hibiscus sabdariffa extract (HES) as an alternative for statin therapy.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Balqis Faizah Azzahra
AU  - Umi Setyo Cahyanti
AU  - Rifqi Aulia Nurazizah
AU  - Rachmi Fauziah Rahayu
AU  - Yuyun Yueniwati
PY  - 2023
DA  - 2023/06/26
TI  - Literature Review of Atherosclerosis Treatment with Hibiscus Sabdariffa as an Alternative for Statin Therapy
BT  - Proceedings of the International Conference of Medical and Life Science (ICoMELISA 2021)
PB  - Atlantis Press
SP  - 44
EP  - 51
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-208-8_8
DO  - 10.2991/978-94-6463-208-8_8
ID  - Azzahra2023
ER  -