Effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice

DOI

10.2991/icmmct-17.2017.132How to use a DOI?

Keywords

Pine bark procyanidins extract, Diabetes, Blood glucose, Blood lipid, Antioxidation.

Abstract

Objective: To study the effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice. Methods: Diabetic mice model was made by intraperitoneal injection of Streptozotocin (STZ). Diabetic mouse were randomly divided into model group, Metformin group (250mg/kg), pine bark procyanidins extract high-dose group (400mg/kg), middle-dose group (200mg/kg) and low-dose group (100mg/kg). Fasting blood glucose was measured after continuous intragastric administration 8 weeks. Blood samples were taken out from the tail of diabetic mice to measure fasting blood glucose;Then blood samples were taken out from the eyeball to measure the serum activity of superoxide dismutase (SOD), INS content, MDA content and blood lipid level. Results: Pine bark procyanidins extract high and middle-dose group can significantly lower the blood glucose level in STZ induced diabetic mice; Serum INS content in pine bark procyanidins extract high-dose group was higher than the model group significantly (p<0.05); Serum SOD content in pine bark procyanidins extract high and middle-dose group was higher than the model group significantly (p<0.05); Serum MDA content in pine bark procyanidins extract high-dose group was lower than the model group significantly (p<0.05); TG TC in pine bark procyanidins extract middle-dose group and LDL-C content in pine bark procyanidins extract high-dose group were lower than the model group significantly (p<0.05); HDL-C content in pine bark procyanidins extract high-dose group was higher than the model group significantly (p<0.05). Conclusion: The pine bark procyanidins extract had a significant effects on reducing blood glucose, antioxidation and improving blood lipid level in STZ induced diabetic mice.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Fang Wang
AU  - Jun Wang
AU  - Meiping Ren
AU  - Bo Hu
PY  - 2017/04
DA  - 2017/04
TI  - Effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice
BT  - Proceedings of the 2017 5th International Conference on Machinery, Materials and Computing Technology (ICMMCT 2017)
PB  - Atlantis Press
SP  - 630
EP  - 636
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmmct-17.2017.132
DO  - 10.2991/icmmct-17.2017.132
ID  - Wang2017/04
ER  -