Proceedings of the 2016 4th International Conference on Machinery, Materials and Computing Technology

Synthesis of 5-(4-bromophenyl) - 4, 6- dichloropyrimidine

Authors
Shanshan Hou, Chen Chen, Ping Wang, Chao Sun, Pengwu Zheng, Shan Xu
Corresponding Author
Shanshan Hou
Available Online March 2016.
DOI
https://doi.org/10.2991/icmmct-16.2016.151How to use a DOI?
Keywords
Dimethyl2-(4-bromophenyl)malonate;5-(4-bromophenyl)pyrimidine-4,6-diol; 5-(4-bromophenyl)-4,6-dichloropyrimidine; Synthesis.
Abstract
The pyrimidine compounds are a class of nitrogen-containing heterocyclic compounds. 5-(4-bromophenyl)-4, 6-dichloropyrimidine is an important intermediate in the synthesis of pyrimidines, dimethyl2-(4-bromophenyl) malonate and 5-(4-bromophenyl) pyrimidine-4,6-diol are important intermediates in compound 1. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available methyl 2-(4-bromophenyl) acetate through three steps. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 52.8% (calculated from methyl 2-(4-bromophenyl) acetate).
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Proceedings
2016 4th International Conference on Machinery, Materials and Computing Technology
Part of series
Advances in Engineering Research
Publication Date
March 2016
ISBN
978-94-6252-165-0
ISSN
2352-5401
DOI
https://doi.org/10.2991/icmmct-16.2016.151How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Shanshan Hou
AU  - Chen Chen
AU  - Ping Wang
AU  - Chao Sun
AU  - Pengwu Zheng
AU  - Shan Xu
PY  - 2016/03
DA  - 2016/03
TI  - Synthesis of 5-(4-bromophenyl) - 4, 6- dichloropyrimidine
BT  - 2016 4th International Conference on Machinery, Materials and Computing Technology
PB  - Atlantis Press
SP  - 772
EP  - 775
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmmct-16.2016.151
DO  - https://doi.org/10.2991/icmmct-16.2016.151
ID  - Hou2016/03
ER  -