Synthesis of 5-(4-bromophenyl) - 4, 6- dichloropyrimidine
Shanshan Hou, Chen Chen, Ping Wang, Chao Sun, Pengwu Zheng, Shan Xu
Available Online March 2016.
- https://doi.org/10.2991/icmmct-16.2016.151How to use a DOI?
- Dimethyl2-(4-bromophenyl)malonate;5-(4-bromophenyl)pyrimidine-4,6-diol; 5-(4-bromophenyl)-4,6-dichloropyrimidine; Synthesis.
- The pyrimidine compounds are a class of nitrogen-containing heterocyclic compounds. 5-(4-bromophenyl)-4, 6-dichloropyrimidine is an important intermediate in the synthesis of pyrimidines, dimethyl2-(4-bromophenyl) malonate and 5-(4-bromophenyl) pyrimidine-4,6-diol are important intermediates in compound 1. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available methyl 2-(4-bromophenyl) acetate through three steps. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 52.8% (calculated from methyl 2-(4-bromophenyl) acetate).
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Shanshan Hou AU - Chen Chen AU - Ping Wang AU - Chao Sun AU - Pengwu Zheng AU - Shan Xu PY - 2016/03 DA - 2016/03 TI - Synthesis of 5-(4-bromophenyl) - 4, 6- dichloropyrimidine BT - 2016 4th International Conference on Machinery, Materials and Computing Technology PB - Atlantis Press SP - 772 EP - 775 SN - 2352-5401 UR - https://doi.org/10.2991/icmmct-16.2016.151 DO - https://doi.org/10.2991/icmmct-16.2016.151 ID - Hou2016/03 ER -