Evaluation of Effects and Mechanism of Hedysarum Polybotys Saccharide on Ventricular Remodeling in Mice Model

DOI

10.2991/icmmct-16.2016.78How to use a DOI?

Keywords

Hedysarum Polybotys Saccharide; isoprenaline; ventricular remodeling

Abstract

Objective To study the effects and mechanism of Hedysarum Polybotys Saccharide (HPS) on ventricular remodeling induced by isoprenaline (ISO) in the mouse. Methods Ventricular remodeling model was induced by subcutaneous injections of ISO for continuous fourteen days. Mice were randomly divided into control group, ISO group, low-dose group, middle-dose group and high-dose group of HPS were introduced by intergalactic (fig.) administration for twenty one days.Cardiac mass index of mouse was calculated at the end of experiment, hydroxyproline (Hyp) content, nitric oxide (NO) content, nitric oxide synthase (NOS) activity, superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in myocardial tissue were measured by spectrophotometry. Results Compared with control group, the heart weight index and Hyp content in ISO group was significantly increased (p<0.01), the SOD activity was decreased (p<0.01) and MDA content was increased (p<0.01), the NOS activity and NO level were reduced (p<0.05, p<0.01). Compared with the ISO group, HPS group could reduce the heart weight index obviously (p<0.05), inhibited the Hyp content, increased SOD activity and reduced MDA content, enhanced NOS activity and NO level in myocardium (p<0.05 and p<0.01). Conclusion HPS have inhibitory effects on ventricular remodeling induced by ISO in mice. Its mechanisms may be related to increasing NOS activity and NO level, in addition to enhancing the antioxidant ability of heart.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Bo Liu
AU  - Weisi Feng
AU  - Qiuyang Yu
AU  - Mingcheng Li
AU  - Ruowen Zhang
PY  - 2016/03
DA  - 2016/03
TI  - Evaluation of Effects and Mechanism of Hedysarum Polybotys Saccharide on Ventricular Remodeling in Mice Model
BT  - Proceedings of the 2016 4th International Conference on Machinery, Materials and Computing Technology
PB  - Atlantis Press
SP  - 385
EP  - 389
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmmct-16.2016.78
DO  - 10.2991/icmmct-16.2016.78
ID  - Liu2016/03
ER  -