Preparation of carboxymethylated polysaccharides from mycelia of Catathelasma ventricosum and their antidiabetic properties

DOI

10.2991/icmemtc-16.2016.15How to use a DOI?

Keywords

Antioxidant; Hypoglycemic; Polysaccharide; Optimization; Carboxymethylation

Abstract

Theahoroacetic acid method under the alkaline condition is adopted to conduct carboxymethylation modification of catathelasmaventricosum polysaccharides (CVPs) to obtain carboxymethylationcatathelasmaventricosumpolysaccharides (cCVPs). In order to improve the acquiring rate (A) and degree of substitution of cCVPs, the synthetic process has been optimized. The optimal condition is: the concentration of NaOH is 20%; the dosage of monochloro acetic acid is 3g; the isopropanol is 15ml; the reaction temperature is 65 ; the response time is 4h; the molecular weight is 5.0×103-1.0×104 Da. The final A and DS of cCVPs obtained reach 82.01% and 0.891, respectively. Besides, the regulating level of cCVPsof the oxidative stress level within the body of mice suffering from diabetes is also studied. Experimental results suggest that carboxymethylation can significantly improve the antioxidant activity of the CVPs.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yiwen Li
AU  - Yuxian You
AU  - Qianqian Tang
AU  - Siqi Zeng
AU  - Di Chen
AU  - Qing Zhang
AU  - Aiping Liu
AU  - Chaohui Feng
AU  - Cheng Li
AU  - Yuntao Liu
PY  - 2016/04
DA  - 2016/04
TI  - Preparation of carboxymethylated polysaccharides from mycelia of Catathelasma ventricosum and their antidiabetic properties
BT  - Proceedings of the 2016 3rd International Conference on Materials Engineering, Manufacturing Technology and Control
PB  - Atlantis Press
SP  - 73
EP  - 80
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmemtc-16.2016.15
DO  - 10.2991/icmemtc-16.2016.15
ID  - Li2016/04
ER  -