Preparation of carboxymethylated polysaccharides from mycelia of Catathelasma ventricosum and their antidiabetic properties
- DOI
- 10.2991/icmemtc-16.2016.15How to use a DOI?
- Keywords
- Antioxidant; Hypoglycemic; Polysaccharide; Optimization; Carboxymethylation
- Abstract
Theahoroacetic acid method under the alkaline condition is adopted to conduct carboxymethylation modification of catathelasmaventricosum polysaccharides (CVPs) to obtain carboxymethylationcatathelasmaventricosumpolysaccharides (cCVPs). In order to improve the acquiring rate (A) and degree of substitution of cCVPs, the synthetic process has been optimized. The optimal condition is: the concentration of NaOH is 20%; the dosage of monochloro acetic acid is 3g; the isopropanol is 15ml; the reaction temperature is 65 ; the response time is 4h; the molecular weight is 5.0×103-1.0×104 Da. The final A and DS of cCVPs obtained reach 82.01% and 0.891, respectively. Besides, the regulating level of cCVPsof the oxidative stress level within the body of mice suffering from diabetes is also studied. Experimental results suggest that carboxymethylation can significantly improve the antioxidant activity of the CVPs.
- Copyright
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Yiwen Li AU - Yuxian You AU - Qianqian Tang AU - Siqi Zeng AU - Di Chen AU - Qing Zhang AU - Aiping Liu AU - Chaohui Feng AU - Cheng Li AU - Yuntao Liu PY - 2016/04 DA - 2016/04 TI - Preparation of carboxymethylated polysaccharides from mycelia of Catathelasma ventricosum and their antidiabetic properties BT - Proceedings of the 2016 3rd International Conference on Materials Engineering, Manufacturing Technology and Control PB - Atlantis Press SP - 73 EP - 80 SN - 2352-5401 UR - https://doi.org/10.2991/icmemtc-16.2016.15 DO - 10.2991/icmemtc-16.2016.15 ID - Li2016/04 ER -