Study on Silk/Carbamate Films

DOI

10.2991/icmeim-17.2017.52How to use a DOI?

Keywords

Silk Fibroin,Carbamate,Blend Film,Cytocompatibility, Cornea Stroma Regeneration

Abstract

In this work, silk fibroin/carbamate blend films are fabricated in different ratios to improve the appropriate properties required for corneal stroma cell regeneration on the films. The structure of the films, the moisture content, protein dissolution loss rate, mechanical properties and light transmittance are investigated. The cytocompatibility of the films is tested with keratinocytes. The result shows that silk II crystalline structure in the film increases with the increase of carbamate content in the film. The light transmittance of the films is above 85%. The light transmittance at wet state is increased when the films are dipped in deionized water at room temperature for 24 hours. The tensile strength and elongation at break of the films are high enough for regeneration of corneal stroma cells both in dry and wet states. The blended films are able to support adhesion and proliferation of keratinocytes. This fibroin-carbamate blend films may offer an option for the corneal tissue engineering application.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Hua Fu
AU  - Zhu-ping Yin
AU  - Feng Wu
AU  - Kai Liu
AU  - Shen-zhou Lu
PY  - 2017/02
DA  - 2017/02
TI  - Study on Silk/Carbamate Films
BT  - Proceedings of the 2017 International Conference on Manufacturing Engineering and Intelligent Materials (ICMEIM 2017)
PB  - Atlantis Press
SP  - 314
EP  - 322
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmeim-17.2017.52
DO  - 10.2991/icmeim-17.2017.52
ID  - Fu2017/02
ER  -