Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials

Preparation of a Thermosensitive Guanidine-Chitosan/Poloxamer in situ Gel for Intranasal Delivery System

Authors
Yingzong Ren, Xue-Jie Qi, Yuanlu Cui
Corresponding Author
Yingzong Ren
Available Online July 2015.
DOI
10.2991/icimm-15.2015.129How to use a DOI?
Keywords
Themosensitive hydrogel; Orthogonal Design; Guanidine-Chitosan; Poloxamer
Abstract

A novel themosensitive in situ gel was prepared by using Poloxamer407 and poloxamer188 combined with membrane penetration enhancer Guanidine-Chitosan. Orthogonal experiment optimization was used to study of formulations conditions that suit to intranasal drug delivery. The optimal intranasal gel formulation has been further checked for viscosity behavior against temperature. The result showed that the optimal formulation was 18% P407 (w/w), 3% P188 (w/w), 2% GCS (w/w), which have prospective gelation temperature 29.5 °C. Evaluation of Guanidine-chitosan influence in gelation temperature showed slight decrease the point of hydrogel system.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials
Series
Advances in Engineering Research
Publication Date
July 2015
ISBN
978-94-62520-88-2
ISSN
2352-5401
DOI
10.2991/icimm-15.2015.129How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Yingzong Ren
AU  - Xue-Jie Qi
AU  - Yuanlu Cui
PY  - 2015/07
DA  - 2015/07
TI  - Preparation of a Thermosensitive Guanidine-Chitosan/Poloxamer in situ Gel for Intranasal Delivery System
BT  - Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials
PB  - Atlantis Press
SP  - 686
EP  - 689
SN  - 2352-5401
UR  - https://doi.org/10.2991/icimm-15.2015.129
DO  - 10.2991/icimm-15.2015.129
ID  - Ren2015/07
ER  -