Base-Catalyzed Synthesis of Pyridopyrimidinone Derivatives

DOI

10.2991/icimm-15.2015.49How to use a DOI?

Keywords

4-Cyano-5-aminopyrazole; pyridopyrimidinone derivatives; cyclocondensation; PDF conversion.

Abstract

Nitrogen-containing heterocyclic compounds become main trend of chemical materials gradually due to its structure diversification, high selectivity, low toxicity and other environmental- friendly characteristics. Meanwhile, it is very important in pharmaceutical research and development. Wherein, people pay more and more attention to pyrazole compounds because of its wide utility, strong efficiency and other features. In the paper, 4-cyano-5-aminopyrazole derivatives 3, synthesized by the condensation of hydrazine and methylene malononitrile, cyclocondensation with aldehyde catalyzed by NaOH to provide pyridopyrimidinone derivatives. The structures of compounds 4 were represented by IR, 1 H NMR, 13 C NMR and MS.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Peng Yang
AU  - Daxin Shi
AU  - Mingxing Liu
AU  - Jiarong Li
PY  - 2015/07
DA  - 2015/07
TI  - Base-Catalyzed Synthesis of Pyridopyrimidinone Derivatives
BT  - Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials
PB  - Atlantis Press
SP  - 256
EP  - 260
SN  - 2352-5401
UR  - https://doi.org/10.2991/icimm-15.2015.49
DO  - 10.2991/icimm-15.2015.49
ID  - Yang2015/07
ER  -