Proceedings of the 1st International Conference on Inter-professional Health Collaboration (ICIHC 2018)

The Effect of Ethanol Extract of Noni (Leaves Morinda citrifolia) on Parasitemia in Balb/c Mice infected with  Plasmodium bergh

Authors
Jon Farizal, Leni Marlina, Susiwati
Corresponding Author
Jon Farizal
Available Online April 2019.
DOI
10.2991/icihc-18.2019.69How to use a DOI?
Keywords
Parasitemia, Morinda citrifolia, Plasmodium berghei
Abstract

Malaria fever is a disease that is still a problem in developing countries. Plasmodium berghei is a facultative intracellular parasite, the immune system that plays a role in the cellular system. Morinda citrifolia is a traditional medicinal plant that contains many active compounds that can reduce the number of malaria Parisemia. Objective: To prove the effect of ethanol extract morinda citrifolia  on the decrease of malaria parasitemia of Balb / c mice infected by Plasmodium berghei. Methods: This type of research was experimental with the design of the post test only control group design in experimental animals, balb / c mice consisting of 24 male mice, divided into 4 groups. (K) was a control group infected with Plasmodium berghei, and the treatment group (P1, P2, P3) were given extract morinda citrifolia  with multilevel doses (0.32 mg / kgBW / day, 0.64 mg / kgBW / day, 1, 28 mg / kg body weight / day) for 3 days after being infected with Plasmodium berghei as much as 0.1 ml x106 with parasitemia examination results of more than 20%. During 4 days given a multilevel dose of noni leaf extract and the 7th day intravenous blood isolation was carried out followed by parasitemia examination. Data were obtained from the calculation of the number of malaria parasitemia decreases in each field of view. Results: The mean decrease in malaria control paristemia was higher than the treatment group (22.17 x 106) ± (16.65 x 106) with (p = 0.0001). Conclusion: Administration of ethanol extract of Morinda citrifolia can reduce malaria parasitemia in Balb / c mice

Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

Volume Title
Proceedings of the 1st International Conference on Inter-professional Health Collaboration (ICIHC 2018)
Series
Advances in Health Sciences Research
Publication Date
April 2019
ISBN
978-9462-52-707-2
ISSN
2468-5739
DOI
10.2991/icihc-18.2019.69How to use a DOI?
Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Jon Farizal
AU  - Leni Marlina
AU  - Susiwati
PY  - 2019/04
DA  - 2019/04
TI  - The Effect of Ethanol Extract of Noni (Leaves Morinda citrifolia) on Parasitemia in Balb/c Mice infected with  Plasmodium bergh
BT  - Proceedings of the 1st International Conference on Inter-professional Health Collaboration (ICIHC 2018)
PB  - Atlantis Press
SP  - 312
EP  - 315
SN  - 2468-5739
UR  - https://doi.org/10.2991/icihc-18.2019.69
DO  - 10.2991/icihc-18.2019.69
ID  - Farizal2019/04
ER  -