Peculiarities of Homeostatic and Genetic Profile in Women With Miscarriage Contaminated With Hydroxybenzol

DOI

10.2991/ahsr.k.201001.040How to use a DOI?

Keywords

miscarriage, hydroxybenzene contamination, homeostasis markers, SULT1A1 gene, PPARG gene

Abstract

The analysis of the features of homeostatic markers and genetic polymorphism in women of fertile age, whose anamnesis is characterized by the presence of reproductive disorders in the form of miscarriage associated with the excessive contamination of biomedia with hydroxybenzene of technogenic origin. Changes in the parameters of regulation and metabolism were revealed in the form of an increase in the level of phosphorus, AST to the upper limit of the norm, and a decrease in the level of total cholesterol. It was found that the C allele and the C/C genotype of peroxisome gene PPARG Pro12Ala rs1801282 act as factors of undesirable reproductive events (miscarriage). At the same time, the G/G genotype of the SULT1A1 gene Arg213His rs9282861 acts as a factor associated with the conditions of increased blood contamination with phenol, abolishing the synthesis of sex steroid, modifying lipoprotein metabolism with a drop in total cholesterol in women with miscarriage.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - O.A. Kazakova
AU  - V.B. Alekseev
AU  - O.O. Sinitsyna
AU  - O.V. Dolgikh
PY  - 2020
DA  - 2020/10/03
TI  - Peculiarities of Homeostatic and Genetic Profile in Women With Miscarriage Contaminated With Hydroxybenzol
BT  - Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)
PB  - Atlantis Press
SP  - 199
EP  - 203
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.201001.040
DO  - 10.2991/ahsr.k.201001.040
ID  - Kazakova2020
ER  -