Lead Specific and Nonspecific Resistance Indices in Adolescents With Bronchial Asthma When Exposed to Vehicle Emissions

DOI

10.2991/ahsr.k.201001.059How to use a DOI?

Keywords

adolescents, air pollutants, malondialdehyde, diene conjugates, immune system, antioxidant enzymes

Abstract

The paper presents the relationship between air pollution, recorded in Veliky Novgorod, with maximum one-time concentrations of phenol, dust, and nitrogen dioxide and the number of appointments made by adolescents with bronchial asthma to see an allergist. It provides data on the amount of CD3+, CD4+, CD8+, CD3- CD16 & CD56+, CD19+, malondialdehyde, and diene conjugates in their blood. During the experiments Wistar rats were exposed to diesel exhaust for two weeks. The authors studied the content of diene conjugates and malondialdehyde in the plasma and erythrocytes of animals on days 3, 6 and 9, as well as the dynamics of antioxidant enzymes such as glutathione reductase, glutathione synthetase, glutathione peroxidase in lung tissues. There was a tendency for increased absolute content of CD3+ and CD19+, as compared to healthy adolescents (p=0.037 and p=0.039, respectively). The relative content of CD8+ and CD4+ tended to decrease (p=0.029 and 0.031, respectively). There was an increase in the content of malondialdehyde in the plasma of patients with bronchial asthma (1.21±0.02 μmol/ml, p<0.001) and diene conjugates (120.56±52.31 lmh/lip p<0.005). The experimental animals had an increased amount of malondialdehyde and diene conjugates in plasma and erythrocytes on the 3rd day. The activity of glutathione reductase, glutathione synthetase, and glutathione peroxidase reduced in the lung tissues at all observation times.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - T.I. Okonenko
AU  - L.G. Proshina
AU  - A.V. Proshin
AU  - G.A. Antropova
AU  - E.E. Rumyantsev
PY  - 2020
DA  - 2020/10/03
TI  - Lead Specific and Nonspecific Resistance Indices in Adolescents With Bronchial Asthma When Exposed to Vehicle Emissions
BT  - Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)
PB  - Atlantis Press
SP  - 291
EP  - 296
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.201001.059
DO  - 10.2991/ahsr.k.201001.059
ID  - Okonenko2020
ER  -