Proceedings of the 2nd International Conference on Education and Technology (ICETECH 2021)

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Does Centella Asiatica Have Antiaging Activity in Skincare Products?

Authors
Gabriella Chandrakirana Krisnamurti1, Dewi Ratih Tirto Sari2, 3, *
1Biotechnology Program, School of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, 10150 Bang Khun Thian, Bangkok, Thailand
2Department of Biology, Faculty of Mathematics and Natural science, Brawijaya University Jl. Veteran Malang, Ketawanggede, Malang, Jawa Timur. Indonesia. 65145
3Research Center of Smart Molecule of Natural Genetics Resources, Brawijaya University, Jl. Veteran Malang, Ketawanggede, Malang, Jawa Timur. Indonesia. 65145
*Corresponding author. Email: dratih303@gmail.com
Corresponding Author
Dewi Ratih Tirto Sari
Available Online 6 January 2022.
DOI
10.2991/assehr.k.220103.035How to use a DOI?
Keywords
Aging; Castilliferol; Castillicetin; Centella asiatica; matrix metalloproteinase
Abstract

This study provided the mechanism of two main compounds of C. asiatica to prevent aging processes by computational analysis. Castilliferol and castillicetin were retrieved from PubChem database, matrix metalloproteinase or MMP involved MMP3, MMP9, and MMP12 also taken out from protein data bank (PDB). Two compounds and MMPs were docked using HEX 8.0 version and analyzed using Discovery Studio 4.1. Castilliferol and castillicetin bound to MMPs (MMP3, MMP9, and MMP12) in several amino acid residues, which were identified as active sites and catalytic sites of MMP3 and MMP9. In contrast, castilliferol and castillicetin inhibited MMP12 allosterically and might change the MMP conformation and reduce the MMP’s activities. The binding free energy among Castilliferol and castillicetin with MMPs performed varied values binding free energy with hydrogen bond, hydrophobic interaction, and electrostatic. Castillicetin demonstrated lower binding free energy in MMP3 and MMP12, while castilliferol showed lower binding free energy in MMP9. Low binding free energy predicted that the compounds have tight ligand – protein interaction. This study suggested that C.asiatica compounds performed antiaging and further in vitro or in vivo analysis are required.

Copyright
© 2022 The Authors. Published by Atlantis Press SARL.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the 2nd International Conference on Education and Technology (ICETECH 2021)
Series
Advances in Social Science, Education and Humanities Research
Publication Date
6 January 2022
ISBN
978-94-6239-508-4
ISSN
2352-5398
DOI
10.2991/assehr.k.220103.035How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press SARL.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - Gabriella Chandrakirana Krisnamurti
AU  - Dewi Ratih Tirto Sari
PY  - 2022
DA  - 2022/01/06
TI  - Does Centella Asiatica Have Antiaging Activity in Skincare Products?
BT  - Proceedings of the 2nd International Conference on Education and Technology (ICETECH 2021)
PB  - Atlantis Press
SP  - 240
EP  - 245
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220103.035
DO  - 10.2991/assehr.k.220103.035
ID  - Krisnamurti2022
ER  -