The Effect of Diabetes Mellitus’s Duration on Platelet Count and Mean Platelet Volume’s Rat Stroke Model

DOI

10.2991/978-94-6463-048-0_2How to use a DOI?

Keywords

Platelet; MPV; DM; Stroke

Abstract

Hiperglikemia in Type 2 Diabetes Mellitus (DM) have an impact on increasing the coagulation activity of the human homeostatic system. DM is a comorbidity of stroke. An increase of Platelet Count (PC) and Mean Platelet Volume (MPV) is useful for assessing the prognosis and severity of ischemic stroke. Research about the effect of diabetic duration on PC-MPVs rat stroke model is limited. This study was purposed to identify the effect of Diabetes Mellitus’s duration on PC-MPVs rat stroke model. This research was an experimental study with posttest control group design. A total 24 male wistar rats aged 3–4 months were randomly divided into four groups. Group 1,2,3 and 4 are a sham, rat stroke model without DM, stroke + 2 weeks DM and stroke + 3 weeks DM. Diabetic rat was induced by Streptozotocin-Nicotinamide injection, with fasting blood glucose level ≥ 126 mg/dL. Rat stroke model was performed with 20 min Bilateral Common Carotid Artery Occlusion (BCCAO) and 24 h reperfusion. PC and MPV tests were performed in clinical laboratories at the end of study. The data was tested by One Way ANOVA. There was an effect of duration of Type-2 DM on PC (p = 0.001) and MPV (p = 0.047) in BCCAO. There was a significant difference (p = 0.009) PC in group 1 (1095800 ± 169893,202 mm3) vs group 2 (648000 ± 175945,067 mm3) and group 2 vs group 3 (1113857,14 ± 205721,842 mm3, p = 0.003). There was a significant difference (p = 0.048) MPV in group 1(7,44 ± 0,51fL) vs group 2 (8,03 ± 0,46 fL) and group 1 vs group 4 (8,08 ± 0,6 fL, p = 0.047). There is an effect of DM duration to platelet count and MPV on rat stroke models.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Nabila Nabila
AU  - Rahma Yuantari
AU  - Ety Sari Handayani
PY  - 2022
DA  - 2022/12/19
TI  - The Effect of Diabetes Mellitus’s Duration on Platelet Count and Mean Platelet Volume’s Rat Stroke Model
BT  - Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)
PB  - Atlantis Press
SP  - 3
EP  - 9
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-048-0_2
DO  - 10.2991/978-94-6463-048-0_2
ID  - Nabila2022
ER  -