Proceedings of the 3rd International Conference on Computation for Science and Technology

Molecular Docking Studies of Flavonoids of Noni Fruit (Morinda citrifolia L.) to Peroxisome Proliferator-Activated Receptor-Gamma (PPAR )

Authors
Fikry Awaluddin, Andrianopsyah Mas Jaya Putra, Supandi Supandi
Corresponding Author
Fikry Awaluddin
Available Online January 2015.
DOI
10.2991/iccst-15.2015.18How to use a DOI?
Keywords
Diabetes, morindacitrifolia, PPAR , flavonoid, molecular docking
Abstract

Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the produced insulin. Morinda citrifolia has been widely used as herbal medicine to prevent and to treat diabetes as well as health supplements. It contains flavonoids which may act as an antidiabetic agent. One of the receptors that play a role in the treatment of diabetes is peroxisome proliferator-activated receptor - gamma (PPAR ) which responsible for insulin sensitization in adipose tissue. In this study, the interaction beetween flavonoids contained in noni fruit as ligands, and PPAR was investigated by using the Autodock Vina software. Some flavonoids such as quercetin, kaempferol, nicotifloroside, narcissoside, and rutin were included in this study. Rosiglitazone, a known ligand for PPAR was used as the standard. The result revealed that all the selected flavonoids showed binding energy ranging between –8,1 kcal/mol to –8,5 kcal/mol. Eventhough, when compared with rosiglitazone (–8.9 kcal/mol), the value of the binding energy of flavonoids was higher, but close to rosiglitazone. This suggests that those flavonoid compounds may show comparable potential with rosiglitazone as antidiabetic agent.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 3rd International Conference on Computation for Science and Technology
Series
Advances in Computer Science Research
Publication Date
January 2015
ISBN
978-94-62520-46-2
ISSN
2352-538X
DOI
10.2991/iccst-15.2015.18How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Fikry Awaluddin
AU  - Andrianopsyah Mas Jaya Putra
AU  - Supandi Supandi
PY  - 2015/01
DA  - 2015/01
TI  - Molecular Docking Studies of Flavonoids of Noni Fruit (Morinda citrifolia L.) to Peroxisome Proliferator-Activated Receptor-Gamma (PPAR )
BT  - Proceedings of the 3rd International Conference on Computation for Science and Technology
PB  - Atlantis Press
SP  - 95
EP  - 99
SN  - 2352-538X
UR  - https://doi.org/10.2991/iccst-15.2015.18
DO  - 10.2991/iccst-15.2015.18
ID  - Awaluddin2015/01
ER  -