Toxicity Prediction of meso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl] porphyrin and meso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl],10,20-diphenyl porphyrin

DOI

10.2991/iccst-15.2015.6How to use a DOI?

Keywords

ADMET, radionuclides,porphyrin, Toxicity Prediction

Abstract

Porphyrin and its derivatives are widely investigated for cancer therapy because of their high selectivity to cancer cells. By labeling gamma and beta emitting-radionuclides to a porphyrin which selectively binds to the cancer tissue will produce a safe and potential radiopharmaceutical. The present study aims to predict the toxicity of meso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl]-porphyrin (D3,4BCPP) andmeso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl],10,20-diphenylporphyrin (D3,4BCPDPP) as well as their complexes with Rhenium (Re).Toxicity prediction using ADMET Predictor™ showed that D3,4BCPP has an acute toxicity in rat; D3,4BCPDPP has an acute toxicity in rat and hepatotoxic; Re-D3,4BCPP has an acute toxicity in rat, hepatotoxic, and likely carcinogenic in rat in which requiring microsomal activation mechanism; and Re-D3,4BCPDPP has an acute toxicity in rat and hepatotoxic.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Fauzan Zein Muttaqin
AU  - Slamet I. Surantaatmadja
AU  - Abdul Mutalib
AU  - Daryono H. Tjahjono
PY  - 2015/01
DA  - 2015/01
TI  - Toxicity Prediction of meso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl] porphyrin and meso-5,15-di[3,4-bis(carboxymethylenoxy)phenyl],10,20-diphenyl porphyrin
BT  - Proceedings of the 3rd International Conference on Computation for Science and Technology
PB  - Atlantis Press
SP  - 25
EP  - 31
SN  - 2352-538X
UR  - https://doi.org/10.2991/iccst-15.2015.6
DO  - 10.2991/iccst-15.2015.6
ID  - ZeinMuttaqin2015/01
ER  -