Stress effects of low-frequency stimulation on the c-Fos and endothelin-1 changes in tree shrew

DOI

10.2991/iccse-15.2015.18How to use a DOI?

Keywords

Low-frequency stimulation, Tree shrew, Endothelin, Brain

Abstract

The chronic low-frequency stimulation could stimulate the expression of c-fos gene in the prefrontal cortex and enhance the endothelin-1 (ET-1) levels of liver and spleen in tree shrew (Tupaia). Our results suggested that application of chronic low-frequency stimulations yielded significant c-Fos protein expression in the prefrontal cortex of tree shrews. After 3 h of death, the average ET-1 concentrations of the live and spleen in both control and treatment groups were significantly decreased by 30.2%-20.5% and 21.3%-22.5%, respectively. The ET-1 levels of the liver and spleen are highly correlated over the elapsed time periods in both control and treatment groups. The significant enhancement of the c-fos gene expression and the ET-1 level suggested that c-fos gene and ET-1 play an important role in the defensive mechanisms against stress stimuli. The ET-1 postmortem changes could be used to estimate the postmortem intervals during the decay process.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Farong Yu
AU  - Xiuzhen Lian
AU  - Mingren Xie
AU  - Wen Yu
AU  - Lirong Guo
AU  - Zhang Zhennan
AU  - Li Denglou
AU  - Zhang Shishuang
PY  - 2015/07
DA  - 2015/07
TI  - Stress effects of low-frequency stimulation on the c-Fos and endothelin-1 changes in tree shrew
BT  - Proceedings of the 2015 International Conference on Computational Science and Engineering
PB  - Atlantis Press
SP  - 101
EP  - 107
SN  - 2352-538X
UR  - https://doi.org/10.2991/iccse-15.2015.18
DO  - 10.2991/iccse-15.2015.18
ID  - Yu2015/07
ER  -