The Episiotomy Effect of Topical Combination of Cinnamon Oil and Red Betel on Skin Wound Healing Mechanism

Emelda; Ratih Devi Alfiana; Nurul Kusumawardani; Yolanda; Sitarina Widyarini

doi:10.2991/ahsr.k.211105.021

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The Episiotomy Effect of Topical Combination of Cinnamon Oil and Red Betel on Skin Wound Healing Mechanism

Authors

Emelda¹^{, *}, Ratih Devi Alfiana², Nurul Kusumawardani¹, Yolanda¹, Sitarina Widyarini³

¹Pharmacy Study Program, Faculty of Health Sciences, Alma Ata University, Yogyakarta 55184, Indonesia

²Midwifery Study Program, Alma Ata University Yogyakarta Indonesia

³Department of Pathology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia

^*Corresponding author. Email: emelda@almaata.ac.id

Corresponding Author

Emelda

Available Online 17 November 2021.

DOI: 10.2991/ahsr.k.211105.021 How to use a DOI?
Keywords: Cinnamon oil; Red betel; Episiotomy; Skin wound healing; Perineum pain
Abstract: The process of episiotomy surgery during childbirth results in injury and pain in the perineum. This study aims to evaluate the effect of the topical combination of cinnamon oil and red betel extract on the healing process of episiotomy incision model in Swiss mice. The research subjects were divided into six groups: (I) Negative control, (II) positive control, (III) mice treated with cinnamon oil, (IV) mice treated with red betel extract, (V) mice treated with 2 ml cinnamon oil and 20% red betel extract, and (VI) mice treated with 4 ml cinnamon oil and 40% red betel extract. Each group of mice received a full-thickness skin wound on the back. The incision wound was then applied by using gel two times a day for 5 days which had been prepared previously. The results showed that the combination of cinnamon oil and red betel decreased the area and percentage of the wound, decreased the inflammatory cell infiltration, and increased the vascular endothelial growth factor expression. This study concludes that the combination of cinnamon oil and red betel extract have the potential to accelerate wound healing and reduce perineal pain in episiotomy incision models conducted in Swiss mice.
Copyright: © 2021 The Authors. Published by Atlantis Press International B.V.
Open Access: This is an open access article under the CC BY-NC license.

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Volume Title: Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
Series: Advances in Health Sciences Research
Publication Date: 17 November 2021
ISBN: 10.2991/ahsr.k.211105.021
ISSN: 2468-5739
DOI: 10.2991/ahsr.k.211105.021 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC license.

Cite this article

ris enw bib

TY  - CONF
AU  - Emelda
AU  - Ratih Devi Alfiana
AU  - Nurul Kusumawardani
AU  - Yolanda
AU  - Sitarina Widyarini
PY  - 2021
DA  - 2021/11/17
TI  - The Episiotomy Effect of Topical Combination of Cinnamon Oil and Red Betel on Skin Wound Healing Mechanism
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 144
EP  - 151
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.021
DO  - 10.2991/ahsr.k.211105.021
ID  - 2021
ER  -

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