Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)

Characterization and Antioxidant Activity of Nanoparticles Loaded Jacfruit Leaf Extract (Artocarpus heterophyllus Lamk.)

Authors
Dina Permata Wijaya1, *, Mardiyanto1, Herlina1, Vabiola Besti Delmoda1
1Department of Pharmacy, Faculty of Mathematics and Sciences, Sriwijaya University, Indonesia
*Corresponding author. Email: dinapermatawijaya@unsri.ac.id
Corresponding Author
Dina Permata Wijaya
Available Online 17 November 2021.
DOI
10.2991/ahsr.k.211105.009How to use a DOI?
Keywords
antioxidant; chitosan; DPPH; jackfruit leaf extract; nanoparticles
Abstract

Jackfruit leaves extract (Artocarpus heterophyllus Lamk.) which contained flavonoid as an antioxidant was unstable and sensitive to environmental conditions. Preparation of nanoparticles loaded jackfruit leaf extract aimed to increase the antioxidant activity through optimal delivery system and maintain the stability of flavonoid from jackfruit leaf extract. Nanoparticle preparation used an ionic gelation method with chitosan, sodium alginate, and variation of calcium chloride. Characterization of nanoparticles were particle size, polydispersity index, efficiency of encapsulation, zeta potential, and XRD analysis. Based on the result, the highest percent of encapsulation efficiency in the nanoparticles with the amount of calcium chloride 40 μl was 90,76%. The characterization of nanoparticles, particle size was 244,2 nm, polydispersity index was 0,22, and zeta potential was +26,4 mV. The XRD pattern of nanoparticles loaded jackfruit leaf extract showed jackfruit leaf extract encapsulated into nanoparticles. Antioxidant activity of jackfruit leaf extract increased after encapsulation as indicated by the IC50 for nanoparticles of jackfruit leaf extract was 10,13μg/ml which indicates high antioxidant.

Copyright
© 2021 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
Series
Advances in Health Sciences Research
Publication Date
17 November 2021
ISBN
978-94-6239-450-6
ISSN
2468-5739
DOI
10.2991/ahsr.k.211105.009How to use a DOI?
Copyright
© 2021 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Dina Permata Wijaya
AU  - Mardiyanto
AU  - Herlina
AU  - Vabiola Besti Delmoda
PY  - 2021
DA  - 2021/11/17
TI  - Characterization and Antioxidant Activity of Nanoparticles Loaded Jacfruit Leaf Extract (Artocarpus heterophyllus Lamk.)
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 60
EP  - 64
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.009
DO  - 10.2991/ahsr.k.211105.009
ID  - Wijaya2021
ER  -