Analgesic Effect of the Ethanol Extract of Sisik Naga Leaf (Drymoglossum sp.) on White Male Mice (Mus musculus)

DOI

10.2991/ahsr.k.211105.026How to use a DOI?

Keywords

Analgesic; hotplate test; sisik naga leaf; pain; ANOVA

Abstract

Pain is a sense of discomfort and accompanied by pain due to cell damage to the body. Pain can be overcome with the use of modern medicine and folk remedies. One of the plants that are suspected to be analgesics is the sisik naga leaf (Drymoglossum sp.). This test aims to find out the analgesic effect of sisik naga leaf ethanol extract (Drymoglossum sp.) on white male mice with the Hot Plate Test method. The extraction method is done by maceration with ethanol solvent. A total of 25 mice is divided into 5 groups and are identified in each group. The treatment dose group is 25 mg/ Kg BW (T₂); 50 mg/ Kg BW (T₃); 100 mg/Kg BW (T₄), Na-CMC suspension of 0.5% as negative control (T₀) and antalgin suspension as a comparison (T₁) and phytochemical screening. The dose that gives analgesic effects is 100 mg / Kg BW. The content of compounds contained in sisik naga leaves in the form of flavonoids, alkaloids, glycosides and steroids. Analysis of statistical data in the form of Parametric Test One-Sample Kolmogorov-Smirnov Test (p =0.05), ANOVA, and TUKEY HSD followed by Non Parametric Test namely Kruskhal Wallis.

Copyright

© 2021 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Yessi Febriani
AU  - Muharni Saputri
AU  - Elim Simatupang
PY  - 2021
DA  - 2021/11/17
TI  - Analgesic Effect of the Ethanol Extract of Sisik Naga Leaf (Drymoglossum sp.) on White Male Mice (Mus musculus)
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 182
EP  - 188
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.026
DO  - 10.2991/ahsr.k.211105.026
ID  - Febriani2021
ER  -