Bioinformatics Analysis on Molecular Mechanism of Poria Cocos in Treatment of Jaundice

DOI

10.2991/iccia-16.2016.4How to use a DOI?

Keywords

Poria Cocos; Jaundice; IPA; PubChem.

Abstract

Objective: To study the molecular mechanism of P.cocos in the treatment of Jaundice by building molecular networks and comparing canonical pathways. Methods: Target proteins of P.cocos related genes of Jaundice were searched from Pubchem and Gene databases online respectively. Molecular networks and canonical pathways comparison analyses were performed by IPA. Results: The molecular networks of P.cocos and Jaundice were complex and multifunctional. The 14 target proteins of P.cocos and 33 Homo sapiens genes of Jaundice were found in databases. There were 56 common pathways both related networks. P.cocos could regulate endothelial differentiation Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1 ) and Interleukin-6 (IL-6) in these pathways. Conclusions: P.cocos treat Jaundice by regulatingmany effective nodes of Metabolism pathway and Immunity related pathways.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Shan Si
AU  - Nie Peng
AU  - Jiang Li
AU  - Yuwen Yan
AU  - Xiaojun Yan
PY  - 2016/09
DA  - 2016/09
TI  - Bioinformatics Analysis on Molecular Mechanism of Poria Cocos in Treatment of Jaundice
BT  - Proceedings of the 2016 International Conference on Computer Engineering, Information Science & Application Technology (ICCIA 2016)
PB  - Atlantis Press
SP  - 18
EP  - 22
SN  - 2352-538X
UR  - https://doi.org/10.2991/iccia-16.2016.4
DO  - 10.2991/iccia-16.2016.4
ID  - Si2016/09
ER  -