Proceedings of the 2016 6th International Conference on Applied Science, Engineering and Technology

Anti-hepatocarcinoma Effects of Resveratrol Loaded Solid Nanodispersion by a New Material Nano Silica

Authors
Xiang-ping Meng, Yi-fei Wang, Zhi-ping Wang
Corresponding Author
Xiang-ping Meng
Available Online May 2016.
DOI
10.2991/icaset-16.2016.59How to use a DOI?
Keywords
Nano silica, Solid nanodispersion, Resveratrol, Cytotoxicity, Antitumor activity, HepG2 cells
Abstract

Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Resveratrol (Res), a major symbol ingredient in red grapes and peanuts, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Res-solid nanodispersion (Res-SND) composed of Res, poloxamer 188 and nano silica was prepared by high pressure homogenization and sieving methods. The in vitro anti-hepatocarcinoma effects of Res-SND relative to efficacy of bulk Res were evaluated. The particle size and zeta potential of Res- SND were 198.6 nm and 14.2mV, respectively. MTT assay showed that Res-SND effectively inhibited the proliferation of HepG2 cells, and the corresponding IC50 values of Res-NS and bulk Res were 2.23 and 7.13 æg/ml. These results suggest that the delivery of Res-SND is a promising approach for treating tumors.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 6th International Conference on Applied Science, Engineering and Technology
Series
Advances in Engineering Research
Publication Date
May 2016
ISBN
978-94-6252-186-5
ISSN
2352-5401
DOI
10.2991/icaset-16.2016.59How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Xiang-ping Meng
AU  - Yi-fei Wang
AU  - Zhi-ping Wang
PY  - 2016/05
DA  - 2016/05
TI  - Anti-hepatocarcinoma Effects of Resveratrol Loaded Solid Nanodispersion by a New Material Nano Silica
BT  - Proceedings of the 2016 6th International Conference on Applied Science, Engineering and Technology
PB  - Atlantis Press
SP  - 297
EP  - 302
SN  - 2352-5401
UR  - https://doi.org/10.2991/icaset-16.2016.59
DO  - 10.2991/icaset-16.2016.59
ID  - Meng2016/05
ER  -