Proceedings of the International Conference on Applied Science and Engineering (ICASE 2018)

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Activity of Sambiloto Extract (Andrographis paniculata Ness) in Reducing Total Blood Cholesterol Levels Hypercholesterolemia Rats

Authors
Ms. Sudarmi, Wiwik Darmini, Ms. Wartini
Corresponding Author
Ms. Sudarmi
Available Online October 2018.
DOI
10.2991/icase-18.2018.33How to use a DOI?
Keywords
blood cholesterol level, hypercholesterolemia , Sambiloto extract
Abstract

Cholesterol is one of the causes of coronary heart disease. The research objective is Assessing dosege of Sambiloto extract in reducing blood cholesterol levels rats (Rattus norvegicus) hypercholesterolemia. The research method is experimental, using Completely Randomized Design (CRD) 3 replications, 6 treatments are: 1) D0 = normal control; 2) D1 = positive control of cholesterol; 3) D2 = comparator simvastatin 2mg/200 g body weight; 4) D3 = dose of 100 mg sambiloto/200 g body weight; 5) D4 = dose 200 mg sambiloto / 200 g body weight; 6) D5 = dose of 400 mg sambiloto/200 g body weight. Rats that have been tested are white male Wistar rats aged 2 months, weight ± 200 g. Analysis using Anova, and further test using DMRT, α 5%. The results of the experiment showed that sambiloto extract of 100 mg/200 g body weight, 200 mg/200 g body weight; 400 mg/200 g body weight and a simvastatin comparator 2 mg/200 g body weight all of that can reduce the total cholesterol level of rats blood that be made hypercholesterolemia. Interestingly, the dose of 400 mg/200 g body weight has the same ability as simvastatin dose of 2 mg/200 g body weight in reducing total blood cholesterol levels of rats by 51%, considering the risk of hypocholesterolemia.

Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the International Conference on Applied Science and Engineering (ICASE 2018)
Series
Advances in Engineering Research
Publication Date
October 2018
ISBN
10.2991/icase-18.2018.33
ISSN
2352-5401
DOI
10.2991/icase-18.2018.33How to use a DOI?
Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Ms. Sudarmi
AU  - Wiwik Darmini
AU  - Ms. Wartini
PY  - 2018/10
DA  - 2018/10
TI  - Activity of Sambiloto Extract (Andrographis paniculata Ness) in Reducing Total Blood Cholesterol Levels Hypercholesterolemia Rats
BT  - Proceedings of the International Conference on Applied Science and Engineering (ICASE 2018)
PB  - Atlantis Press
SP  - 120
EP  - 122
SN  - 2352-5401
UR  - https://doi.org/10.2991/icase-18.2018.33
DO  - 10.2991/icase-18.2018.33
ID  - Sudarmi2018/10
ER  -