Proceedings of the International Conference on Advances in Nano-Neuro-Bio-Quantum (ICAN 2023)

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Epigenetic Regulations, Motif and Pathway Identification of Myelofibrosis Chip Sequences

Authors
Sravani Sane1, *, I. A. Shylesh Murthy2, Preenon Bagchi3
1Padmashree Institute of Management and Sciences, Bengaluru, India
2Junior Researcher, Vasishth Academy of Advanced Studies and Research, Bengaluru, India
3Institute of Biosciences and Technology, MGM University, Aurangabad, India
*Corresponding author. Email: sanesravani836@gmail.com
Corresponding Author
Sravani Sane
Available Online 17 November 2023.
DOI
10.2991/978-94-6463-294-1_15How to use a DOI?
Keywords
Chromatin immunoprecipitation (ChIP); Myelofibrosis; Next Generation sequencing; PCR duplicates; MACS2 Callpeak; Motif; KEGG pathway
Abstract

Next generation sequence technique that is Chromatin immunoprecipitation (ChIP) on the ChIP–Seq of Myelofibrosis. Myelofibrosis is a type of blood cancer which is also considered as a form of chronic leukemia. It is two types primary myelofibrosis and secondary myelofibrosis its leads to complication of an autoimmune disease, additional disease features include hepatosplenomegaly, extramedullary hematopoiesis (EMH) etc., In this work, I have retrieved its chip-Seq from SRA database, removed the PCR duplicates and finally identified the genome enriched region using the MAC2 call peak tool This annotated peak table was used to identify the motifs present in the chip-Seq of Myelofibrosis. Peak table was annotated to identify the genes and the corresponding pathways was identified from the KEGG pathway.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International Conference on Advances in Nano-Neuro-Bio-Quantum (ICAN 2023)
Series
Advances in Health Sciences Research
Publication Date
17 November 2023
ISBN
10.2991/978-94-6463-294-1_15
ISSN
2468-5739
DOI
10.2991/978-94-6463-294-1_15How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Sravani Sane
AU  - I. A. Shylesh Murthy
AU  - Preenon Bagchi
PY  - 2023
DA  - 2023/11/17
TI  - Epigenetic Regulations, Motif and Pathway Identification of Myelofibrosis Chip Sequences
BT  - Proceedings of the International Conference on Advances in Nano-Neuro-Bio-Quantum (ICAN 2023)
PB  - Atlantis Press
SP  - 178
EP  - 191
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-294-1_15
DO  - 10.2991/978-94-6463-294-1_15
ID  - Sane2023
ER  -