The Perturbation Toxic Effect of Graphene on HepG2 Cell

DOI

10.2991/icaemt-15.2015.17How to use a DOI?

Keywords

graphene, HepG2, metabolomics, toxicity

Abstract

How to accurately and comprehensively unveil the toxic effect of graphene on the cells have always received extensive attention by many researchers. Owing to the opposition results in classical assay approaches, some researchers have attempted to adopt advanced analysis techniques. Our group successful performed mass spectrometry-based metabolomics to investigate the toxic effect of graphene on the HepG2. In this analysis platform, by pattern recognition and metabolism analysis, we acquired twelve potential biomarkers and two main disturbed metabolism pathway involving in glutathione metabolism and arginine and proline metabolism. Our findings demonstrated that the graphene stimulate the HepG2 cell and results in breaking the homeostasis and perturbation the metabolism pathway, we should focus on this disturbance from the graphene.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Guozheng Jiao
AU  - Xin Li
AU  - Junqiang Qiu
AU  - Ning Zhang
AU  - Hongying Xu
AU  - Shumin Liu
PY  - 2015/08
DA  - 2015/08
TI  - The Perturbation Toxic Effect of Graphene on HepG2 Cell
BT  - Proceedings of the 2015 International Conference on Advanced Engineering Materials and Technology
PB  - Atlantis Press
SP  - 85
EP  - 89
SN  - 2352-5401
UR  - https://doi.org/10.2991/icaemt-15.2015.17
DO  - 10.2991/icaemt-15.2015.17
ID  - Jiao2015/08
ER  -