Synthesis of 4- (Thieno [3, 2-d] pyrimidin-4-yl) Morpholine

DOI

10.2991/emcm-16.2017.113How to use a DOI?

Keywords

4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine; Synthesis; Intermediate

Abstract

4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives is an important intermediate which inhibited tumor necrosis factor alpha and nitric oxide. In this work, a rapid and green synthetic method for compound (5) was established. The compound (5) was synthesized from the commercially available methyl 3-aminothiophene-2-carboxylate and formamidine acetate through three steps including condensation reaction, chlorination, and nucleophilic substitution. The structure was confirmed by 1H NMR and MS. Furthermore, the total yield of the three steps was 43%.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Huajun Lei
AU  - Linxiao Wang
AU  - Yingjia Xiong
AU  - Zhou Lan
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 4- (Thieno [3, 2-d] pyrimidin-4-yl) Morpholine
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.113
DO  - 10.2991/emcm-16.2017.113
ID  - Lei2017/02
ER  -