Synthesis of Cinnamic Acid Derivatives

DOI

10.2991/emcm-16.2017.85How to use a DOI?

Keywords

Cinnamic derivatives, Synthesis, Optimization

Abstract

Quinazoline derivatives have been shown to be biologically active such as afatinib. The cinnamic acid derivative is an important part of the quinazoline derivative which exerts its activity. And Cinnamic acid derivatives were prepared by the benzaldehyde derivatives and malonic acids. In this paper, four cinnamic acid derivatives were prepared. The structure was confirmed by MS and 1H NMR. In addition, this method not only saved the reaction time, but also improved the purity of the product. The yield of the step was about 90%.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Lei Zhao
AU  - Yuanbiao Tu
AU  - Yuping Guo
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of Cinnamic Acid Derivatives
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.85
DO  - 10.2991/emcm-16.2017.85
ID  - Zhao2017/02
ER  -