Formulation and Evaluation of Ethanol Extract Emulgel Preparation of Durian (Durio zibethinus) Skin Waste Combination of Kaempferiae Rhizoma Extract as Analgesic-Anti-Inflammation

DOI

10.2991/ahsr.k.200523.058How to use a DOI?

Keywords

emulgel, analgetic anti-inflammation, durian extract

Abstract

Durian skin waste that has not been utilized properly, because of it’s difficult to decompose character, has the potential to become one of the biological wastes that can cause environmental pollution (Prabowo, 2009). Even though some studies have stated that durian rind has the potential as an anti-inflammatory only in that study, the largest dose was given (400 mg / Kg BW) activity is still not better than the comparator Na.diklofenak 0.9 / 200 g BW (Azizah and fitriani, 2015). Comparable to durian kencur production was so high in Indonesia. Inexpensive and beneficial for people’s lives making kencur as one of the most popular types of plants, because all people can consume it. Empirically based on kencur can be used as painkillers. Besides being empirical-based, several studies have stated that kencur extract can affect experimental animals better than acetosal in terms of reducing pain in mice at a dose of 32 mg / 20 g BW of mice. (imaningrum, 2010). The purpose of this study is the utilization of waste by combining it with one of Indonesia’s natural ingredients by making an emulgel preparation formulation and conducting in vivo testing which is tested on white Wistar rats to prove the analgesic-anti-inflammatory effect of a combination of durian and kencur skin as a topical treatment to be able to reduce or even eliminate a feeling of pain. Evaluations carried out are organoleptic, homogeneity, pH, viscosity, rheology, centrifugation test, storage stability test at room temperature for 28 days, and spreadability. The results of the study explained that emulgel preparations containing ethanol extract of durian rind combined with kencur rhizome extract had good physical quality as topical preparations.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Fajar Setiawan
AU  - Lusi Nurdianti
PY  - 2020
DA  - 2020/06/08
TI  - Formulation and Evaluation of Ethanol Extract Emulgel Preparation of Durian (Durio zibethinus) Skin Waste Combination of Kaempferiae Rhizoma Extract as Analgesic-Anti-Inflammation
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 237
EP  - 243
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.058
DO  - 10.2991/ahsr.k.200523.058
ID  - Setiawan2020
ER  -