Synthesis of Nitrogen-containing 4-alkoxybenzaldehyde Analogues

DOI

10.2991/bst-17.2018.40How to use a DOI?

Keywords

Nitrogen-containing 4-alkoxybenzaldehyde, Synthesis

Abstract

Nitrogen-containing 4-alkoxybenzaldehyde analogues as a kind of water-soluble aldehyde are important intermediates for small molecule anticancer drugs. A rapid and high yield synthetic method for nitrogen-containing 4- alkoxybenzaldehyde analogues was established in this work. The target compound was synthesized from the commercially available 4-alkoxybenzaldehyde through two steps nucleophilic substitution. The structure of the target product was confirmed by 1HNMR and MS. In addition, the synthetic method was optimized. The total yield of the two steps was high up to 99%.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zhen Xiao
AU  - Sheng Tang
AU  - Xiao-Lei Wang
AU  - Peng-Wu Zheng
AU  - Shan Xu
PY  - 2018/02
DA  - 2018/02
TI  - Synthesis of Nitrogen-containing 4-alkoxybenzaldehyde Analogues
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 259
EP  - 262
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.40
DO  - 10.2991/bst-17.2018.40
ID  - Xiao2018/02
ER  -