Growth Inhibition of Shenfoweikang Herbs on Gastric Carcinoma Via Signal Transduction Pathways

DOI

10.2991/bst-17.2018.6How to use a DOI?

Keywords

Shenfoweikang, Mechanism, Signal Transduction Pathways, Gastric Carcinoma.

Abstract

To verify the anti-tumor effect of the Shenfoweikang on gastric cancer, BALB/C mice grafted with a mouse gastric adenocarcinoma cell line MFC was used as the experimental model. The mice received Shenfoweikang herbs over a 60-day period starting at the first day. The tumor size was periodically measured. Apoptotic indices (AI) were examined by the TUNEL method and flow cytometric analysis. The expression of VEGF, STAT3 and DEC1 in tumor tissues was examined by immunostaining. Compared with the control group, tumor growth in the mice treated with Shenfoweikang decoction were significantly inhibited (P<0.05). AI in the mice was significantly increased after the Shenfoweikang decoction treatment. The expressions of VEGF, STAT3 and DEC1 in tumor tissues were down-regulated after treated with Shenfoweikang decoction. The anti-tumor effect of Shenfoweikang herbs is related with the induction of the cell apoptosis and down-regulation of VEGF, STAT3 and DEC1 signal transduction system.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiao-Ping Wang
AU  - Huan-Ping Lin
AU  - Qiao-Xia Wang
AU  - Bing Xu
AU  - Xuan Qu
AU  - Bao-Ning Qi
AU  - Na Chang
PY  - 2018/02
DA  - 2018/02
TI  - Growth Inhibition of Shenfoweikang Herbs on Gastric Carcinoma Via Signal Transduction Pathways
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 37
EP  - 42
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.6
DO  - 10.2991/bst-17.2018.6
ID  - Wang2018/02
ER  -