Serum Leptin Levels in Patients with Hepatitis B: A Meta-analysis

DOI

10.2991/bst-17.2018.1How to use a DOI?

Keywords

Leptin, Hepatitis B virus, Male, Female, Meta-analysis.

Abstract

Background and Aims: Hepatitis B virus (HBV) infection is a widespread disease affecting people worldwide. With more and more research on the deepening of the leptin, which suggested a close relationship between serum leptin levels and HBV. In this study, we explored the correlation between serum leptin levels and HBV through meta-analysis. Methods: Potentially relevant studies between 2007 and 2017 were retrieved from PubMed, Ovid, Embase, Web of Science, Weipu Journal, Chinese Biomedical, China National Knowledge Infrastructure, and Wan Fang Data. Z-test was used to determine the significance of the pooled standardized mean difference (SMD). Results: We analyzed 16 studies, which involved 884 HBV patients and 618 healthy controls. And then pooled the SMD and calculated the 95% confidence interval (CI) by using a random-effects model from heterogeneity analysis. High serum leptin levels were observed in HBV patients (SMD: 1.16, 95%CI: 0.72-1.59, P<0.00001). Stratification analysis on the ethnicity, study design, and detection method revealed significant increases in the serum leptin levels among the Asian population of the ethnicity subgroup, case-control study of the study design subgroup, and ELISA or RIA of the detection method subgroup. Conclusion: This meta-analysis suggests a significant difference between HBV patients and healthy controls. Therefore, serum leptin levels may serve as a prognostic marker for hepatitis B disease.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Qiong-Yuan Zhang
AU  - Xuan Xu
AU  - Mei Luo
AU  - Jian-Jiang Xue
AU  - Ying-Li Li
PY  - 2018/02
DA  - 2018/02
TI  - Serum Leptin Levels in Patients with Hepatitis B: A Meta-analysis
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 1
EP  - 9
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.1
DO  - 10.2991/bst-17.2018.1
ID  - Zhang2018/02
ER  -