Proceedings of the conference BioSangam 2022: Emerging trends in Biotechnology (BIOSANGAM 2022)

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Biofilm Detachment and Its Implication in Spreading Biofilm-Related Infections

Authors
Akshat Gupta1, Anmol Srivastava1, Vishnu Agarwal1, *
1Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad (Prayagraj), 211004, Uttar Pradesh, India
*Corresponding author. Email: vishnua@mnnit.ac.in
Corresponding Author
Vishnu Agarwal
Available Online 14 December 2022.
DOI
10.2991/978-94-6463-020-6_2How to use a DOI?
Keywords
Biofilm; quorum sensing; pathogenicity; dispersion; quorum sensing inhibitor
Abstract

Biofilms are a community of microorganisms formed on both abiotic and biotic surfaces. These colonies play a vital role in the virulent life cycle of bacteria. Bacteria communicate intrinsically and extrinsically to grow and eventually disperse their virulent factors, ultimately leading to diseases. Biofilm dispersion is the last stage in this life cycle; at this stage, the biofilm has completed maturation. The microorganism then disperses as the biofilm ruptures and assumes a planktonic lifestyle until they find a new surface to attach to and repeat the cycle. This mechanism plays a vital role in the pathogenicity of the microorganism and can be triggered prematurely to disrupt the microorganism's virulent nature. In this mini-review, we have summarized biofilm dispersion, its mechanisms, and the factors influenced by, focusing on their effect on the pathogen's virulence. We have also discussed the significance of quorum sensing and the modern methods used to develop quorum sensing inhibitors through in-silico approaches.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the conference BioSangam 2022: Emerging trends in Biotechnology (BIOSANGAM 2022)
Series
Advances in Biological Sciences Research
Publication Date
14 December 2022
ISBN
10.2991/978-94-6463-020-6_2
ISSN
2468-5747
DOI
10.2991/978-94-6463-020-6_2How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Akshat Gupta
AU  - Anmol Srivastava
AU  - Vishnu Agarwal
PY  - 2022
DA  - 2022/12/14
TI  - Biofilm Detachment and Its Implication in Spreading Biofilm-Related Infections
BT  - Proceedings of the conference BioSangam 2022: Emerging trends in Biotechnology (BIOSANGAM 2022)
PB  - Atlantis Press
SP  - 3
EP  - 13
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-020-6_2
DO  - 10.2991/978-94-6463-020-6_2
ID  - Gupta2022
ER  -