Progress in Research on Small Molecules as Gene-targeted Drugs

DOI

10.2991/bep-16.2017.38How to use a DOI?

Keywords

gene-targeted drug; G-quadruplex; polyamide

Abstract

The findings of effective targets and the identification of target binding molecules are two key points in drug discovery. The complete human genome and their rapid increase in structural and functional information led to new possibilities for diagnosis and therapy of diseases, using gene-targeted drugs. Currently, gene-targeted drugs includes groove binders, intercalators, alkylators and cleavage agents and are widely used in cancer, Alzheimer's disease, blood pressure, heart and autoimmune diseases research and therapy. A review on the targeted genes, their interaction molecules and the application on disease therapy is presented.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yanli WANG
AU  - Sijia WANG
AU  - Jun XU
AU  - Wen ZHANG
PY  - 2016/12
DA  - 2016/12
TI  - Progress in Research on Small Molecules as Gene-targeted Drugs
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 182
EP  - 186
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.38
DO  - 10.2991/bep-16.2017.38
ID  - WANG2016/12
ER  -