Effects of Propranolol on Osteoclasts Cultured in Vitro

DOI

10.2991/bep-16.2017.6How to use a DOI?

Keywords

propranolol ,osteoclasts. ,TRAP

Abstract

Objective: To study the effect of propranolol on osteoclasts. Methods: (1)propranolol at the doses of 10^-2 µmol/ml, 10^-3 µmol/ml, 10^-4 µmol/ml, were added into the osteoclasts for coculture for 72 h, then tartrate-resistant acid phosphatase (TRAP) and toluidine blue staining was used to detect the effects of propranolol on osteoclasts. Results: compared with the control group, 10^-2 µmol/ml, 10^-3 µmol/ml, 10^-4 µmol/ml group of propranolol were able to make the number of osteoclasts and bone resorption area decreased (P < 0.05) Conclusion different concentrations of propranolol can inhibit osteoclast bone resorption(P < 0.05).

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiaojuan LI
AU  - Xiaorui XIE
AU  - Jin REN
AU  - Liling REN
AU  - Jian CAO
PY  - 2016/12
DA  - 2016/12
TI  - Effects of Propranolol on Osteoclasts Cultured in Vitro
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 27
EP  - 29
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.6
DO  - 10.2991/bep-16.2017.6
ID  - LI2016/12
ER  -