The Mechanism of Carthamin Yellow Injection Promote Acute Myocardial Infarction Infarct Border Zone Angiogenesis

DOI

10.2991/bbe-16.2016.52How to use a DOI?

Keywords

Carthamin Yellow, Vascular Regeneration, Vascular Endothelial Growth Factor, Acute Myocardial Iinfarction.

Abstract

We observed the impact of carthamin yellow injection on revascularization in rats with acute myocardial infarction and discuss its mechanism. The left anterior descending branches of the coronary arteries of Wistar rats were ligatured, and the animal model with acute myocardial infarction was duplicated. The animals with successful modeling were randomly divided into the model group and treatment group. The rats in the treatment group were injected with carthamin yellow (2.5 mg/Kg•d) for 3, 7 and 14 days. Their weights were measured 24 h after the last drug administration, and their hearts were removed for weighing and blood collection. The Cardiac indices were then measured, and electrocardiograms (ECGs) were recorded. Masson staining was used to determine the microvessel count of the infarct border zone of the myocardium. Immunohistochemistry was used to detect the expression of vascular endothelial growth factor (VEGF). Compared with the model group, the cardiac indices of the rats treated with carthamin yellow for 7 and 14 days were decreased (P < 0.05). The ECGs of these treated rats returned to normal. In the drug administration groups, the number of capillaries at the marginal zone of the myocardial infarction clearly increased (P < 0.05). The immunohistochemical results showed that the expressions of VEGF at the marginal zone of acute myocardial infarction increased (P < 0.05). The injection of carthamin yellow has therapeutical effects on rats with acute myocardial infarction. It can promote the revascularization of the myocardium at the marginal zone of myocardial infarction. This effect could be related to the increase in VEGF expression at the marginal zone of acute myocardial infarction.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Xiaomin Wang
AU  - Zhiyu Zhou
AU  - Yaokun Xiong
AU  - Jiangtao Wei
AU  - Yanting Wan
AU  - Fei Li
AU  - Zhiyong Liu
PY  - 2016/07
DA  - 2016/07
TI  - The Mechanism of Carthamin Yellow Injection Promote Acute Myocardial Infarction Infarct Border Zone Angiogenesis
BT  - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 337
EP  - 344
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.52
DO  - 10.2991/bbe-16.2016.52
ID  - Wang2016/07
ER  -