The Osteoprotective Effect of Zhuanggu-Guanjie Pill in Orchidectomized Mice

DOI

10.2991/bbe-16.2016.44How to use a DOI?

Keywords

Zhuanggu-Guanjie Pill, Male, Mice, Osteoporosis.

Abstract

To verify the osteoprotective effect of Zhuanggu-Guanjie (ZGGJ) in male mice. The male mice were randomly divided into 6 groups: control group (sham-operation), model group (orchidectomy group), three ZGGJ groups at doses of 0.77, 1.54 and 3.08g/kg, as well as Alendronate sodium group as positive control. ZGGJ was intragastric administration daily for 8 weeks until mice were executed followed anesthesia. ZGGJ can ameliorate osteoporosis with increasing bone strength and improve trabecular bone microstructure which was proved by the Micro-CT scan. Serum osteocalcin (OC), alkaline phosphatase (ALP) and tartrate resistant acid phosphatase (TRACP) were examined, and the decreased OC implied the reduction of bone destruction. These results suggest that ZGGJ pill has significant therapeutic effect on osteoporosis in orchidectomized mice.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiaomei Yuan
AU  - Yanan Bi
AU  - Zeman Yan
AU  - Hong Shi
AU  - Kun Zhou
PY  - 2016/07
DA  - 2016/07
TI  - The Osteoprotective Effect of Zhuanggu-Guanjie Pill in Orchidectomized Mice
BT  - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 278
EP  - 282
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.44
DO  - 10.2991/bbe-16.2016.44
ID  - Yuan2016/07
ER  -