Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to MMP-9,TIMP-1 of IgA Nephropathy Model Rat

DOI

10.2991/bbe-16.2016.35How to use a DOI?

Keywords

Tonifying kidney and spleen, Detoxification of throat method, IgA nephropathy, Rat, MMP-9, TIMP-1.

Abstract

Purpose:To study the method of tonifying kidney and spleen, detoxification of throat in treatment of IgA nephropathy. Methods:72 Wistar rats were randomly divided into blank group, model group, Lotensin group, tonifying the kidney and spleen, detoxification of method of high, medium and low dose group (hereinafter referred to as TCM high, medium and low dose group). The IgAN rat model was established by oral administration of BSA and LPS intravenous injection method. Observed after treatment for 8 weeks rats in each phase of urine red blood cell count, 24h urinary protein (UTP) and renal tissue MMP-9, TIMP-1 changes. Results:1) compared with the model group, rats 24h UTP has declined. The TCM medium dose group decreased significantly (P0.05). 3) compared with the blank group, the content of MMP-9 in renal tissue of the rats in the model group decreased significantly, the content of TIMP-1 increased significantly, and MMP-9/TIMP-1 decreased (P

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Di Zou
AU  - Yinping Wang
AU  - Tianying Chang
AU  - Shoulin Zhang
PY  - 2016/07
DA  - 2016/07
TI  - Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to MMP-9,TIMP-1 of IgA Nephropathy Model Rat
BT  - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 211
EP  - 216
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.35
DO  - 10.2991/bbe-16.2016.35
ID  - Zou2016/07
ER  -