Anti-fatigue Effects of the Genistein Supplementation in Mice Subjected to Forced Swimming Test

DOI

10.2991/bbe-16.2016.23How to use a DOI?

Keywords

Genistein, Anti-fatigue, Forced swimming test, Biochemical analysis, Mice.

Abstract

The present study was designed to evaluate the anti-fatigue effects of genistein in mice subjected to the forced swimming test. Mice were divided into four groups, i.e., one control group and three genistein treated groups. The treated groups were received doses of genistein (7, 15 and 30 mg/kg) dissolved in 1.0 mL of physiological saline, and the control group received same volume of physiological saline via oral gavage once a day. After 28 days, the mice were subjected to the forced swimming test, along with the determination of exhaustive swimming times and some biochemical parameters. The results showed that genistein could prolong exhaustive swimming time of mice, which was accompanied by decreases in blood lactic acid (BLA) and serum urea nitrogen (SUN) levels, increases in liver and muscle glycogen contents, and superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels in serum. This indicated that genistein had anti-fatigue effects.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Qiongli Hu
PY  - 2016/07
DA  - 2016/07
TI  - Anti-fatigue Effects of the Genistein Supplementation in Mice Subjected to Forced Swimming Test
BT  - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 137
EP  - 142
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.23
DO  - 10.2991/bbe-16.2016.23
ID  - Hu2016/07
ER  -