Exocyst Regulates Drosophila Border Cell Migration and Wing Development
- https://doi.org/10.2991/bbbs-18.2018.36How to use a DOI?
- Drosophila exocyst; Drosophila melanogaster; Sec3-GFP.
Cell migration plays an important role in many physiological and pathological processes. Understanding of the mechanisms of cell migration may lead us to develop novel therapeutic strategies for controlling human disease. Border cell migration in the ovary of Drosophila melanogaster has emerged as an excellent model for studying cell migration in vivo. In a previous study, we have found that the gene sec3 that encodes a component of Drosophila exocyst is required for border cell migration. In the following study, we found that high levels of Sec3-GFP are seen in the leading edge of migratory border cells, and sec3 functions together with other genes encoding exocyst components. Moreover, knockdown of exocyst components induces aberrant wing development. The results implicates that exocyst components play important roles in Dosophila border cell migration and wing development, and function as a complex as they have been found in yeast.
- © 2018, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Ping Wan AU - Sumei Zheng AU - Ting Liao PY - 2018/04 DA - 2018/04 TI - Exocyst Regulates Drosophila Border Cell Migration and Wing Development BT - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018) PB - Atlantis Press SP - 165 EP - 168 SN - 2468-5747 UR - https://doi.org/10.2991/bbbs-18.2018.36 DO - https://doi.org/10.2991/bbbs-18.2018.36 ID - Wan2018/04 ER -